Effect of 5-HTTLPR on current source density, connectivity, and topological properties of resting state EEG networks

Ekaterina A. Proshina, Alexander N. Savostyanov, Andrey V. Bocharov, Gennady G. Knyazev

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The S allele of serotonin transporter gene (5-HTTLPR) has been found to increase the risk of depression and other mental health problems, but some evidence suggests that S-allele carriers outperform subjects carrying the long allele in an array of cognitive tasks. Evidence linking this polymorphism with individual variation in electrophysiological properties of resting state brain networks is very limited. This study investigated the effect of 5-HTTLPR polymorphism on EEG current source density, connectivity, and topological properties of resting state networks. We collected genetic and resting state EEG data in 113 Caucasians. As compared to L-homozygotes, S-allele carriers showed lower current source density and connectivity in most frequency bands in areas overlapping with the default mode and emotion regulation regions. The analysis of graph-theoretical measures showed that S-allele carriers, as compared to L-homozygotes, have less optimal topological properties of brain networks in theta, but more optimal in alpha band. This dissociation may reflect the predisposition to emotional disorders, which is inherent to S-allele carriers, and, on the other hand, their superior functioning in some cognitive domains.

Original languageEnglish
Pages (from-to)67-75
Number of pages9
JournalBrain Research
Volume1697
DOIs
Publication statusPublished - 15 Oct 2018

Keywords

  • 5-HTTLPR
  • Connectivity
  • EEG
  • Graph theory
  • Resting state
  • sLORETA
  • DEFAULT MODE NETWORK
  • COGNITIVE PERFORMANCE
  • ALZHEIMERS-DISEASE
  • FUNCTIONAL CONNECTIVITY
  • SEROTONIN TRANSPORTER GENE
  • EMOTIONAL STIMULI
  • POLYMORPHISM 5-HTTLPR
  • STRESSFUL LIFE EVENTS
  • CORTICAL THICKNESS
  • BRAIN NETWORKS
  • Humans
  • Male
  • Rest/physiology
  • Connectome/methods
  • Young Adult
  • Serotonin Plasma Membrane Transport Proteins/genetics
  • Adult
  • Cerebral Cortex/physiology
  • Female
  • Neural Pathways/metabolism
  • Electroencephalography/methods
  • Gene Frequency
  • Brain/physiology
  • Genotype
  • Polymorphism, Genetic/genetics
  • Membrane Potentials
  • Electrophysiological Phenomena

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