Dual DNA topoisomerase 1 and tyrosyl-DNA phosphodiesterase 1 inhibition for improved anticancer activity

Alexandra Zakharenko, Nadezhda Dyrkheeva, Olga Lavrik

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)

Abstract

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that catalyzes the hydrolysis of the phosphodiester bond in the DNA-topoisomerase 1 (Top1) covalent complex and repairs some other 3′-end DNA adducts. Currently, Tdp1 functions as an important target in cancer drug design owing to its ability to break down various DNA adducts induced by chemotherapeutics. Tdp1 inhibitors may sensitize tumor cells to the action of Top1 poisons, thereby potentiating their effects. This mini-review summarizes findings from studies reporting the combined inhibition of Top1 and Tdp1. Two different approaches have been considered for developing such drug precursors.

Original languageEnglish
Pages (from-to)1427-1441
Number of pages15
JournalMedicinal Research Reviews
Volume39
Issue number4
DOIs
Publication statusPublished - 1 Jul 2019

Keywords

  • Tdp1 inhibitors
  • Top1 poisons
  • topoisomerase 1
  • tyrosyl-DNA phosphodiesterase 1 (Tdp1)
  • tyrosyl-DNA phosphodiesterase 2

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