DNA damage response and resistance of cancer stem cells

Etna Abad, Dmitry Graifer, Alex Lyakhovich

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

The cancer stem cell (CSC) model defines tumors as hierarchically organized entities, containing a small population of tumorigenic CSC, or tumour-initiating cells, placed at the apex of this hierarchy. These cells may share common qualities with chemo- and radio-resistant cancer cells and contribute to self-renewal activities resulting in tumour formation, maintenance, growth and metastasis. Yet, it remains obscure what self-defense mechanisms are utilized by these cells against the chemotherapeutic drugs or radiotherapy. Recently, attention has been focused on the pivotal role of the DNA damage response (DDR) in tumorigenesis. In line with this note, an increased DDR that prevents CSC and chemoresistant cells from genotoxic pressure of chemotherapeutic drugs or radiation may be responsible for cancer metastasis. In this review, we focus on the current knowledge concerning the role of DDR in CSC and resistant cancer cells and describe the existing opportunities of re-sensitizing such cells to modulate therapeutic treatment effects.

Original languageEnglish
Pages (from-to)106-117
Number of pages12
JournalCancer Letters
Volume474
DOIs
Publication statusPublished - 1 Apr 2020

Keywords

  • Chemoresistance
  • DNA damage and repair
  • Radioresistance
  • Tumour-initiating cells
  • INITIATING CELLS
  • INCREASED EXPRESSION
  • DRUG-RESISTANCE
  • REPAIR PATHWAYS
  • EPITHELIAL-MESENCHYMAL TRANSITION
  • BREAST-CANCER
  • RADIATION-RESISTANCE
  • HOMOLOGOUS-RECOMBINATION
  • ESOPHAGEAL CANCER
  • CHEMOTHERAPY RESISTANCE

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