Diverse developmental strategies of x chromosome dosage compensation in eutherian mammals

Alexander I. Shevchenko, Elena V. Dementyeva, Irina S. Zakharova, Suren M. Zakian

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

In eutherian mammals, dosage compensation arose to balance X-linked gene expression between sexes and relatively to autosomal gene expression in the evolution of sex chromosomes. Dosage compensation occurs in early mammalian development and comprises X chromosome upregulation and inactivation that are tightly coordinated epigenetic processes. Despite a uniform principle of dosage compensation, mechanisms of X chromosome inactivation and upregulation demonstrate a significant variability depending on sex, developmental stage, cell type, individual, and mammalian species.The review focuses on relationships between X chromosome inactivation and upregulation in mammalian early development.

Original languageEnglish
Pages (from-to)223-233
Number of pages11
JournalInternational Journal of Developmental Biology
Volume63
Issue number3-5
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • Dosage compensation
  • Mammal
  • X chromosome inactivation
  • X chromosome upregulation
  • Xist
  • MOUSE
  • LINKED GENES
  • dosage compensation
  • ACTIVE X
  • PLURIPOTENT STEM-CELLS
  • FACULTATIVE HETEROCHROMATIN
  • NONCODING RNA
  • INACTIVATION
  • mammal
  • XIST RNA
  • GENE-EXPRESSION
  • UP-REGULATION
  • Pluripotent Stem Cells/cytology
  • Genomic Imprinting
  • Epigenesis, Genetic
  • Male
  • RNA, Long Noncoding/genetics
  • Female
  • Rodentia/embryology
  • Gene Silencing
  • Animals
  • X Chromosome
  • Up-Regulation/genetics
  • X Chromosome Inactivation/genetics

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