Discrepancy between thermodynamic and kinetic stabilities of the: Tert -butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying

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5 Citations (Scopus)

Abstract

The tert-butanol (TBA)-water system is studied in relation to increasing the efficiency of obtaining pharmaceutical powders by freeze-drying. Trehalose was used as a model target product. We report the X-ray diffraction and thermal analysis data which add surprising new information to the phase diagram of this previously repeatedly studied system. The freezing protocol has a strong impact on the specific surface area of the trehalose freeze-dried cakes and on the primary drying time. This is related to a discrepancy between the kinetic and thermodynamic stabilities of several TBA hydrates: di-hydrate (H1), heptahydrate (H2), and decahydrate (H3).

Original languageEnglish
Pages (from-to)4262-4265
Number of pages4
JournalChemical Communications
Volume55
Issue number29
DOIs
Publication statusPublished - 17 Apr 2019

Keywords

  • Drug Stability
  • Freeze Drying
  • Kinetics
  • Powders
  • Thermodynamics
  • tert-Butyl Alcohol/chemistry
  • COSOLVENT SYSTEMS
  • DESIGN
  • BUTYL ALCOHOL
  • ICE NUCLEATION
  • LYOPHILIZATION
  • QUALITY ATTRIBUTES
  • PROCESS PERFORMANCE
  • PHASE-DIAGRAM

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