Discrepancy between thermodynamic and kinetic stabilities of the: Tert -butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying

A. G. Ogienko; A. S. Stoporev; A. A. Ogienko; M. S. Mel'Gunov; T. P. Adamova; A. S. Yunoshev; A. Yu Manakov; E. V. Boldyreva

doi:10.1039/c9cc00397e

Discrepancy between thermodynamic and kinetic stabilities of the: Tert -butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying

A. G. Ogienko, A. S. Stoporev, A. A. Ogienko, M. S. Mel'Gunov, T. P. Adamova, A. S. Yunoshev, A. Yu Manakov, E. V. Boldyreva

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The tert-butanol (TBA)-water system is studied in relation to increasing the efficiency of obtaining pharmaceutical powders by freeze-drying. Trehalose was used as a model target product. We report the X-ray diffraction and thermal analysis data which add surprising new information to the phase diagram of this previously repeatedly studied system. The freezing protocol has a strong impact on the specific surface area of the trehalose freeze-dried cakes and on the primary drying time. This is related to a discrepancy between the kinetic and thermodynamic stabilities of several TBA hydrates: di-hydrate (H1), heptahydrate (H2), and decahydrate (H3).

Original language	English
Pages (from-to)	4262-4265
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	29
DOIs	https://doi.org/10.1039/c9cc00397e
Publication status	Published - 17 Apr 2019

Keywords

Drug Stability
Freeze Drying
Kinetics
Powders
Thermodynamics
tert-Butyl Alcohol/chemistry
COSOLVENT SYSTEMS
DESIGN
BUTYL ALCOHOL
ICE NUCLEATION
LYOPHILIZATION
QUALITY ATTRIBUTES
PROCESS PERFORMANCE
PHASE-DIAGRAM

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Ogienko, A. G., Stoporev, A. S., Ogienko, A. A., Mel'Gunov, M. S., Adamova, T. P., Yunoshev, A. S., Manakov, A. Y., & Boldyreva, E. V. (2019). Discrepancy between thermodynamic and kinetic stabilities of the: Tert -butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying. Chemical Communications, 55(29), 4262-4265. https://doi.org/10.1039/c9cc00397e

Ogienko, A. G. ; Stoporev, A. S. ; Ogienko, A. A. ; Mel'Gunov, M. S. ; Adamova, T. P. ; Yunoshev, A. S. ; Manakov, A. Yu ; Boldyreva, E. V. / Discrepancy between thermodynamic and kinetic stabilities of the : Tert -butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying. In: Chemical Communications. 2019 ; Vol. 55, No. 29. pp. 4262-4265.

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abstract = "The tert-butanol (TBA)-water system is studied in relation to increasing the efficiency of obtaining pharmaceutical powders by freeze-drying. Trehalose was used as a model target product. We report the X-ray diffraction and thermal analysis data which add surprising new information to the phase diagram of this previously repeatedly studied system. The freezing protocol has a strong impact on the specific surface area of the trehalose freeze-dried cakes and on the primary drying time. This is related to a discrepancy between the kinetic and thermodynamic stabilities of several TBA hydrates: di-hydrate (H1), heptahydrate (H2), and decahydrate (H3).",

keywords = "Drug Stability, Freeze Drying, Kinetics, Powders, Thermodynamics, tert-Butyl Alcohol/chemistry, COSOLVENT SYSTEMS, DESIGN, BUTYL ALCOHOL, ICE NUCLEATION, LYOPHILIZATION, QUALITY ATTRIBUTES, PROCESS PERFORMANCE, PHASE-DIAGRAM",

author = "Ogienko, {A. G.} and Stoporev, {A. S.} and Ogienko, {A. A.} and Mel'Gunov, {M. S.} and Adamova, {T. P.} and Yunoshev, {A. S.} and Manakov, {A. Yu} and Boldyreva, {E. V.}",

year = "2019",

month = apr,

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doi = "10.1039/c9cc00397e",

language = "English",

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Ogienko, AG , Stoporev, AS, Ogienko, AA, Mel'Gunov, MS, Adamova, TP, Yunoshev, AS , Manakov, AY & Boldyreva, EV 2019, 'Discrepancy between thermodynamic and kinetic stabilities of the: Tert -butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying', Chemical Communications, vol. 55, no. 29, pp. 4262-4265. https://doi.org/10.1039/c9cc00397e

Discrepancy between thermodynamic and kinetic stabilities of the : Tert -butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying. / Ogienko, A. G.; Stoporev, A. S.; Ogienko, A. A.; Mel'Gunov, M. S.; Adamova, T. P.; Yunoshev, A. S.; Manakov, A. Yu ; Boldyreva, E. V.

In: Chemical Communications, Vol. 55, No. 29, 17.04.2019, p. 4262-4265.

Research output: Contribution to journal › Article › peer-review

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AU - Ogienko, A. G.

AU - Stoporev, A. S.

AU - Ogienko, A. A.

AU - Mel'Gunov, M. S.

AU - Adamova, T. P.

AU - Yunoshev, A. S.

AU - Manakov, A. Yu

AU - Boldyreva, E. V.

PY - 2019/4/17

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KW - Kinetics

KW - Powders

KW - Thermodynamics

KW - tert-Butyl Alcohol/chemistry

KW - COSOLVENT SYSTEMS

KW - DESIGN

KW - BUTYL ALCOHOL

KW - ICE NUCLEATION

KW - LYOPHILIZATION

KW - QUALITY ATTRIBUTES

KW - PROCESS PERFORMANCE

KW - PHASE-DIAGRAM

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VL - 55

SP - 4262

EP - 4265

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 29

ER -

Discrepancy between thermodynamic and kinetic stabilities of the: Tert -butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying

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Keywords

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