Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)-Borneol from Abies sibirica and (+)-Camphor

Anastasiya S. Sokolova, Olga I. Yarovaya, Nikolay I. Bormotov, Larisa N. Shishkina, Nariman F. Salakhutdinov

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

A series of the bornyl ester/amide derivatives with N-containing heterocycles were designed and synthesized as vaccinia virus (VV) inhibitors. Bioassay results showed that among the designed compounds, derivatives 6, 13, 14, 34, 36 and 37 showed the best inhibitory activity against VV with the IC50 values of 12.9, 17.9, 3.4, 2.5, 12.5 and 7.5 μm, respectively, and good cytotoxicity. The primary structure–activity relationship (SAR) study suggested that the combination of a saturated N-heterocycle, such as morpholine or 4-methylpiperidine, and a 1,7,7-trimethylbicyclo[2.2.1]heptane scaffold was favorable for antiviral activity.

Original languageEnglish
Article numbere1800153
Number of pages9
JournalChemistry and Biodiversity
Volume15
Issue number9
DOIs
Publication statusPublished - 1 Sep 2018

Keywords

  • antiviral activities
  • borneol
  • monoterpenoids
  • N-heterocycles
  • orthopoxviruses
  • TECOVIRIMAT
  • EFFICACY
  • BORNEOL DERIVATIVES
  • SMALLPOX
  • ORTHOPOXVIRUS INFECTIONS

Fingerprint

Dive into the research topics of 'Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)-Borneol from Abies sibirica and (+)-Camphor'. Together they form a unique fingerprint.

Cite this