Directed synthesis of fluorine containing 2,3-dihydrobenzo[b][1,4]oxathiine derivatives from polyfluoroarenes

Larisa Politanskaya, Evgeny Tretyakov

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Polyfluorinated 2,3-dihydrobenzo[b][1,4]oxathiines were synthesized starting from monosubstituted hexafluorobenzenes and 2-mercaptoethanol via aromatic nucleophilic substitution of fluorine atoms in good yields. The reactions take place under mild reaction conditions and require readily available starting materials. The possibility of structural modifications of the obtained heterocycles through interaction with phenylethylamine and potassium methylate was demonstrated.

Original languageEnglish
Article number109592
Number of pages7
JournalJournal of Fluorine Chemistry
Volume236
DOIs
Publication statusPublished - 1 Aug 2020

Keywords

  • Aromatic nucleophilic substitution
  • Fluorinated S,O-heterocycles
  • Polyfluorinated 2,3-dihydrobenzo[b][1,4]oxathiines
  • Polyfluorinated 2-(vinylthio)phenol
  • ANTIOXIDANT ACTIVITY
  • KETONES
  • RING
  • Polyfluorinated 2,3-dihydrobenzo[b][1,4] oxathiines
  • CYTOTOXICITY EVALUATION
  • EFFICIENT SYNTHESIS
  • SULFONES

OECD FOS+WOS

  • 1.04 CHEMICAL SCIENCES

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