Development and Validation of a Method for Determination of a New Effective Inhibitor of Influenza Virus H1N1 in Blood Plasma

A. S. Sokolova; O. I. Yarovaya; A. A. Nefedov; N. F. Salakhutdinov

doi:10.1007/s11094-018-1748-y

Development and Validation of a Method for Determination of a New Effective Inhibitor of Influenza Virus H1N1 in Blood Plasma

A. S. Sokolova, O. I. Yarovaya, A. A. Nefedov, N. F. Salakhutdinov

Organic Chemistry Section

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A new GC-MS method for determining an antiviral agent (camphecin) in blood plasma was developed. Sample preparation consisted of precipitating proteins using MeOH. The method was validated for selectivity, calibration curve, accuracy, precision, limit of quantitation, carryover, and stability. The analytical range was 0.1 – 2 μg/mL. The method could be used for pharmacokinetic studies.

Original language	English
Pages (from-to)	1102-1105
Number of pages	4
Journal	Pharmaceutical Chemistry Journal
Volume	51
Issue number	12
DOIs	https://doi.org/10.1007/s11094-018-1748-y
Publication status	Published - Mar 2018

Keywords

camphecin
GC-MS
plasma
validation
A VIRUSES
ANTIVIRAL ACTIVITY
DERIVATIVES

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10.1007/s11094-018-1748-y

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abstract = "A new GC-MS method for determining an antiviral agent (camphecin) in blood plasma was developed. Sample preparation consisted of precipitating proteins using MeOH. The method was validated for selectivity, calibration curve, accuracy, precision, limit of quantitation, carryover, and stability. The analytical range was 0.1 – 2 μg/mL. The method could be used for pharmacokinetic studies.",

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AU - Yarovaya, O. I.

AU - Nefedov, A. A.

AU - Salakhutdinov, N. F.

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KW - GC-MS

KW - plasma

KW - validation

KW - A VIRUSES

KW - ANTIVIRAL ACTIVITY

KW - DERIVATIVES

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