Determination of boron by inductively coupled plasma atomic emission spectroscopy. Biodistribution of 10B in tumor-bearing mice

A. R. Tsygankova; V. V. Kanygin; A. I. Kasatova; E. L. Zav’yalov; T. Ya Gusel’nikova; A. I. Kichigin; R. A. Mukhamadiyarov

doi:10.1007/s11172-020-2805-8

Determination of boron by inductively coupled plasma atomic emission spectroscopy. Biodistribution of ¹⁰B in tumor-bearing mice

A. R. Tsygankova, V. V. Kanygin, A. I. Kasatova, E. L. Zav’yalov, T. Ya Gusel’nikova, A. I. Kichigin, R. A. Mukhamadiyarov

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The determination of boron in animal organ tissues using inductively coupled plasma atomic emission spectroscopy (ICP AES) has been optimized for analytical support of boron neutron capture therapy of cancerous tumors. The proposed technique is universal and rapid. The methodology includes: preliminary acid decomposition at elevated temperatures and pressure (if necessary), determination of boron by ICP AES in the obtained solutions using reference samples based on single-element solutions. The method is verified by spike experiment and varying the weight-samples. The ICP AES technique was used to evaluate the accumulation of boronophenylalanine and borocaptate in mice organs. Biodistribution of ¹⁰B in the case of intravenous administration of the drug to SCID mice with SPF status using the human glioblastoma cell line U87 was investigated.

Original language	English
Pages (from-to)	601-607
Number of pages	7
Journal	Russian Chemical Bulletin
Volume	69
Issue number	3
DOIs	https://doi.org/10.1007/s11172-020-2805-8
Publication status	Published - 1 Mar 2020

Keywords

atomic emission spectroscopy
borocaptate
boron neutron capture therapy
boronophenylalanine
determination of boron
organ tissue
sample preparation
BNCT
DELIVERY
P-BORONOPHENYLALANINE
MICROWAVE DIGESTION
BSH
NEUTRON-CAPTURE THERAPY
MASS SPECTROMETRY
AGENTS
NEBULIZATION

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10.1007/s11172-020-2805-8

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title = "Determination of boron by inductively coupled plasma atomic emission spectroscopy. Biodistribution of 10B in tumor-bearing mice",

abstract = "The determination of boron in animal organ tissues using inductively coupled plasma atomic emission spectroscopy (ICP AES) has been optimized for analytical support of boron neutron capture therapy of cancerous tumors. The proposed technique is universal and rapid. The methodology includes: preliminary acid decomposition at elevated temperatures and pressure (if necessary), determination of boron by ICP AES in the obtained solutions using reference samples based on single-element solutions. The method is verified by spike experiment and varying the weight-samples. The ICP AES technique was used to evaluate the accumulation of boronophenylalanine and borocaptate in mice organs. Biodistribution of 10B in the case of intravenous administration of the drug to SCID mice with SPF status using the human glioblastoma cell line U87 was investigated.",

keywords = "atomic emission spectroscopy, borocaptate, boron neutron capture therapy, boronophenylalanine, determination of boron, organ tissue, sample preparation, BNCT, DELIVERY, P-BORONOPHENYLALANINE, MICROWAVE DIGESTION, BSH, NEUTRON-CAPTURE THERAPY, MASS SPECTROMETRY, AGENTS, NEBULIZATION",

author = "Tsygankova, {A. R.} and Kanygin, {V. V.} and Kasatova, {A. I.} and Zav{\textquoteright}yalov, {E. L.} and Gusel{\textquoteright}nikova, {T. Ya} and Kichigin, {A. I.} and Mukhamadiyarov, {R. A.}",

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doi = "10.1007/s11172-020-2805-8",

language = "English",

volume = "69",

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journal = "Russian Chemical Bulletin",

issn = "1066-5285",

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Determination of boron by inductively coupled plasma atomic emission spectroscopy. Biodistribution of ¹⁰B in tumor-bearing mice. / Tsygankova, A. R.; Kanygin, V. V.; Kasatova, A. I.; Zav’yalov, E. L.; Gusel’nikova, T. Ya; Kichigin, A. I.; Mukhamadiyarov, R. A.

In: Russian Chemical Bulletin, Vol. 69, No. 3, 01.03.2020, p. 601-607.

Research output: Contribution to journal › Article › peer-review

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AU - Tsygankova, A. R.

AU - Kanygin, V. V.

AU - Kasatova, A. I.

AU - Zav’yalov, E. L.

AU - Gusel’nikova, T. Ya

AU - Kichigin, A. I.

AU - Mukhamadiyarov, R. A.

PY - 2020/3/1

Y1 - 2020/3/1

N2 - The determination of boron in animal organ tissues using inductively coupled plasma atomic emission spectroscopy (ICP AES) has been optimized for analytical support of boron neutron capture therapy of cancerous tumors. The proposed technique is universal and rapid. The methodology includes: preliminary acid decomposition at elevated temperatures and pressure (if necessary), determination of boron by ICP AES in the obtained solutions using reference samples based on single-element solutions. The method is verified by spike experiment and varying the weight-samples. The ICP AES technique was used to evaluate the accumulation of boronophenylalanine and borocaptate in mice organs. Biodistribution of 10B in the case of intravenous administration of the drug to SCID mice with SPF status using the human glioblastoma cell line U87 was investigated.

AB - The determination of boron in animal organ tissues using inductively coupled plasma atomic emission spectroscopy (ICP AES) has been optimized for analytical support of boron neutron capture therapy of cancerous tumors. The proposed technique is universal and rapid. The methodology includes: preliminary acid decomposition at elevated temperatures and pressure (if necessary), determination of boron by ICP AES in the obtained solutions using reference samples based on single-element solutions. The method is verified by spike experiment and varying the weight-samples. The ICP AES technique was used to evaluate the accumulation of boronophenylalanine and borocaptate in mice organs. Biodistribution of 10B in the case of intravenous administration of the drug to SCID mice with SPF status using the human glioblastoma cell line U87 was investigated.

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