Design and synthesis of new acridone-based nitric oxide fluorescent probe

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Abstract

Nitric oxide (NO) is an important signaling molecule involved in a wide range of physiological and pathological processes. Fluorescent imaging is a useful tool for monitoring NO concentration, which could be essential in various biological and biochemical studies. Here, we report the design of a novel small-molecule fluorescent probe based on 9(10H)acridone moiety for nitric oxide sensing. 7,8-Diamino-4-carboxy-10-methyl-9(10H)acridone reacts with NO in aqueous media in the presence of O2, yielding a corresponding triazole derivative with fivefold increased fluorescence intensity. The probe was shown to be capable of nitric oxide sensing in living Jurkat cells.

Original languageEnglish
Article number4340
JournalMolecules
Volume26
Issue number14
DOIs
Publication statusPublished - 2 Jul 2021

Keywords

  • 9(10H)acridone
  • Fluorescent probes
  • Nitric oxide probes

OECD FOS+WOS

  • 1.04 CHEMICAL SCIENCES
  • 1.06.CQ BIOCHEMISTRY & MOLECULAR BIOLOGY

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