Deregulation of p53-dependent microRNAs: The results of mathematical modeling

Olga F. Voropaeva, Sof'ya Dmitrievna Senotrusova, Yurii Ivanovitch Shokin

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The mathematical model of the dynamics of the tumor markers network p53-Mdm2-microRNA for microRNA class with a direct positive connection with p53 was formulated. Numerical investigation of the microRNA functioning in conditions of the deregulation of p53 and p53-Mdm2-network was carried out. The deregulation of microRNA in detail was studied. The situations in which p53, its inhibitor Mdm2 and microRNAs exhibit critical properties for the patient's status and can be identified as diagnostic markers of cancer and neurodegenerative disease were studied. The results of numerical analysis are in good agreement with the data of clinical and laboratory studies of known microRNAs.

Original languageEnglish
Pages (from-to)151-175
Number of pages25
JournalMathematical Biology and Bioinformatics
Volume12
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • Delay differential equation
  • Deregulation of miRNAs
  • Mdm2
  • MicroRNA
  • MiR-145
  • MiR-34
  • Numerical simulation
  • Oncological prognosis
  • P53
  • Positive direct connection
  • Transactivation
  • Tumor marker

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