Deconstructing age reprogramming

Prim B. Singh, Petr P. Laktionov, Andrew G. Newman

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

It has been proposed that age reprogramming enables old cells to be rejuvenated without passage through an embryonic stage (Singh and Zacouto in J Biosci 35:315–319, 2010). As such, age reprogramming stands apart from the induced pluripotent stem (iPS) and nuclear transfer-embryonic stem (NT-ES) cell therapies where histo-compatible cells are produced only after passage through an embryonic stage. It avoids many of the disadvantages associated with iPS and NT-ES cell therapies. Experimental evidence in support of age reprogramming is burgeoning. Here, we discuss possible new approaches to enhance age reprogramming, which will have considerable benefits for regenerative therapies.

Original languageEnglish
Article number106
Number of pages7
JournalJournal of Biosciences
Volume44
Issue number4
DOIs
Publication statusPublished - 1 Sep 2019

Keywords

  • Age reprogramming
  • eAge
  • Epigenetic clock
  • Epigenetic rejuvenation
  • iPS cells
  • reprogramming factors
  • CELLS
  • SENESCENT
  • CONVERSION
  • NEURONS
  • HALLMARKS
  • FIBROBLASTS

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