Data for isolation and properties analysis of diastereomers of a mono-substituted phosphoryl guanidine trideoxyribonucleotide

Alexander A. Lomzov, Maxim S. Kupryushkin, Andrey V. Shernyukov, Mikhail D. Nekrasov, Ilya S. Dovydenko, Dmitry A. Stetsenko, Dmitrii V. Pyshnyi

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Abstract

This article presents new data on the properties of the diastereomers of a mono-substituted phosphoryl guanidine trideoxyribonucleotides d(TpCp*A) [1,2]. The data include information on isolation, identification, treatment with snake venom phosphodiesterase and structural analysis by 1D and 2D NMR spectroscopy and restrained molecular dynamics analysis. The data can be used for preparation, analysis, application of phosphoryl guanidine oligonucleotide and for development of new nucleic acids derivatives. This data article is associated with the manuscript titled “Diastereomers of a mono-substituted phosphoryl guanidine trideoxyribonucleotide: isolation and properties” [1].

Original languageEnglish
Article number104148
Pages (from-to)104148
Number of pages25
JournalData in Brief
Volume25
DOIs
Publication statusPublished - 1 Aug 2019

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Keywords

  • Circular dichroism
  • Diastereomer assignment phosphodiesterase digestion assay
  • Molecular dynamics
  • NMR
  • Phosphoryl guanidine oligonucleotide
  • RP-HPLC
  • Spatial structure
  • SOFTWARE

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