Cytotoxicity and Crystal Structures of Nitrosoruthenium Complexes mer-[Ru(NO)Py2Cl3] and mer-[Ru(NO)(γ-Pic)2Cl3]

Alexander N. Makhinya, Julia A. Eremina, Taisiya S. Sukhikh, Iraida A. Baidina, Maxim A. Il'in, Lyubov S. Klyushova, Elizaveta V. Lider

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The reaction of K2[Ru(NO)Cl5] with excess of pyridine or γ-picoline in DMF solution at high temperature gives mer-[Ru(NO)Py2Cl3] (I) and mer-[Ru(NO)(γ-Pic)2Cl3] (II), correspondingly, that were obtained with high yields (∼80%) by filtration of concentrated solutions. There is another method for this synthesis that consists of reaction of the same salt with respective heterocycle in water solution with following evaporation with ethanol addition (yield is ∼95%). The crystal structures of the compounds were determined by X-ray single-crystal diffraction analysis. Synthesized compounds were characterized by elemental analysis, TGA, IR- and NMR-spectroscopy. The title complexes and related compounds fac-[Ru(NO)Py2Cl3] (III), cis-[Ru(NO)Py2Cl2(OH)] (IV), trans-[Ru(NO)Py2Cl2(OH)] (V), trans-[Ru(NO)Py4(OH)]Cl2⋅H2O (VI), trans-[Ru(NO)Py4Cl]Cl2⋅H2O (VII) were examined on cytotoxic activity towards Hep-2 cancer cell line and HEK-293 cell line. All the complexes have shown a dose-dependent cytotoxic effect, complex II has the lowest IC50 value.

Original languageEnglish
Pages (from-to)5866-5871
Number of pages6
JournalChemistrySelect
Volume4
Issue number19
DOIs
Publication statusPublished - 24 May 2019

Keywords

  • cytotoxic activity
  • pyridine
  • ruthenium nitrosyl complexes
  • γ-picoline
  • 2,2'-BIPYRIDINE
  • NO
  • HYDROXO
  • ACID
  • RELEASE
  • gamma-picoline
  • LIGANDS
  • RUTHENIUM COMPLEXES
  • NITRIC-OXIDE
  • TRANSFORMATIONS

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