Cytotoxic and cancer preventive activity of benzotrithioles and benzotrithiole oxides, synthetic analogues of varacins

Alexandra S. Kuzmich, Tatyana M. Khomenko, Sergey N. Fedorov, Tatyana N. Makarieva, Larisa K. Shubina, Nina I. Komarova, Dina V. Korchagina, Tatyana V. Rybalova, Konstantin P. Volcho, Nariman F. Salakhutdinov

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    The cytotoxic and cancer preventive activities of synthetic analogs of natural varacins with polysulfide groups were studied. Presence of a sulfoxide group was found to have no significant effect on the cytotoxicity of these compounds. At the same time, this group is important for inhibition of colony formation of tumor cells treated with tumor promoter thus demonstrating cancer preventive activity. The most promising compound appears to be a synthetic varacin C analog, sulfoxide 10a, which exhibits the cancer preventive activity at dose into 100 times lower than its cytotoxic concentrations.

    Original languageEnglish
    Pages (from-to)397-404
    Number of pages8
    JournalMedicinal Chemistry Research
    Volume26
    Issue number2
    DOIs
    Publication statusPublished - 1 Feb 2017

    Keywords

    • Cancer preventive activity
    • Cytotoxicity
    • Oncology
    • Polysulfide compounds
    • Varacin

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