Cytotoxic and cancer preventive activity of benzotrithioles and benzotrithiole oxides, synthetic analogues of varacins

Alexandra S. Kuzmich, Tatyana M. Khomenko, Sergey N. Fedorov, Tatyana N. Makarieva, Larisa K. Shubina, Nina I. Komarova, Dina V. Korchagina, Tatyana V. Rybalova, Konstantin P. Volcho, Nariman F. Salakhutdinov

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The cytotoxic and cancer preventive activities of synthetic analogs of natural varacins with polysulfide groups were studied. Presence of a sulfoxide group was found to have no significant effect on the cytotoxicity of these compounds. At the same time, this group is important for inhibition of colony formation of tumor cells treated with tumor promoter thus demonstrating cancer preventive activity. The most promising compound appears to be a synthetic varacin C analog, sulfoxide 10a, which exhibits the cancer preventive activity at dose into 100 times lower than its cytotoxic concentrations.

Original languageEnglish
Pages (from-to)397-404
Number of pages8
JournalMedicinal Chemistry Research
Volume26
Issue number2
DOIs
Publication statusPublished - 1 Feb 2017

Keywords

  • Cancer preventive activity
  • Cytotoxicity
  • Oncology
  • Polysulfide compounds
  • Varacin

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