Cytokine Content in the Hypothalamus and Hippocampus of C57Bl/6J Mice with Depressive-Like Behavior

G. V. Idova, E. L. Al’perina, S. Ya Zhanaeva, M. M. Gevorgyan, A. A. Rogozhnikova

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The content of pro- and anti-inflammatory cytokines in the hypothalamus, hippocampus, and blood serum of C57Bl/6J mice with depressive-like behavior induced by 20-day social stress was analyzed in 4 h after immune stimulation with LPS (250 μg/kg). These animals are characterized by a tendency to an increase in the blood content of IL-6 and a decrease in the level of IL-10. Changes in cytokine content in the brain of mice with depressive-like state developed under these conditions were observed only in the hippocampus: the levels of IL-1β, IL-6, TNFα, and IL-10 increased and the content of IFNγ decreased in comparison the corresponding parameters in the controls (not exposed to social stress) and aggressive animals. No changes in the levels of IL-2, IL-4, and IL-17 were revealed in the hypothalamus and hippocampus.

Original languageEnglish
Pages (from-to)11-16
Number of pages6
JournalBulletin of Experimental Biology and Medicine
Volume167
Issue number1
DOIs
Publication statusPublished - 15 May 2019

Keywords

  • depressive-like behavior
  • hippocampus
  • hypothalamus
  • pro- and anti-inflammatory cytokines
  • social stress
  • MECHANISMS

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