Abstract
By recrystallization with different solvents as well as decomposition of betulin ethanol solvate at room temperature a new crystalline form of the biologically active compound betulin, namely hemihydrate of betulin, is obtained. By single crystal X-ray diffraction data the crystal structure of hemihydrate of betulin is determined. By powder X-ray thermodiffraction and differential scanning calorimetry it is found that when hemihydrate of betulin is heated to melting, Н2О molecules are removed and solid-phase transformations occur, which are related to the formation of an intermediate crystalline form andan orthorhombic modification of betulin.
Original language | English |
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Pages (from-to) | 1260-1266 |
Number of pages | 7 |
Journal | Journal of Structural Chemistry |
Volume | 61 |
Issue number | 8 |
DOIs | |
Publication status | Published - 1 Aug 2020 |
Keywords
- betulin
- polymorphism
- pseudopolymorphism
- solid-phase transformations
- SOLVATOMORPHS
- ISOSTRUCTURALITY
- X-RAY