Crystalline form of betulin: polymorphism or pseudopolymorphism?

T. N. Drebushchak; A. V. Mikhailovskaya; V. A. Drebushchak; M. A. Mikhailenko; S. A. Myz’; T. P. Shakhtshneider; S. A. Kuznetsova

doi:10.1134/S0022476620080119

Crystalline form of betulin: polymorphism or pseudopolymorphism?

T. N. Drebushchak, A. V. Mikhailovskaya, V. A. Drebushchak, M. A. Mikhailenko, S. A. Myz’, T. P. Shakhtshneider, S. A. Kuznetsova

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1 Citation (Scopus)

Abstract

By recrystallization with different solvents as well as decomposition of betulin ethanol solvate at room temperature a new crystalline form of the biologically active compound betulin, namely hemihydrate of betulin, is obtained. By single crystal X-ray diffraction data the crystal structure of hemihydrate of betulin is determined. By powder X-ray thermodiffraction and differential scanning calorimetry it is found that when hemihydrate of betulin is heated to melting, Н₂О molecules are removed and solid-phase transformations occur, which are related to the formation of an intermediate crystalline form andan orthorhombic modification of betulin.

Original language	English
Pages (from-to)	1260-1266
Number of pages	7
Journal	Journal of Structural Chemistry
Volume	61
Issue number	8
DOIs	https://doi.org/10.1134/S0022476620080119
Publication status	Published - 1 Aug 2020

Keywords

betulin
polymorphism
pseudopolymorphism
solid-phase transformations
SOLVATOMORPHS
ISOSTRUCTURALITY
X-RAY

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10.1134/S0022476620080119

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title = "Crystalline form of betulin: polymorphism or pseudopolymorphism?",

abstract = "By recrystallization with different solvents as well as decomposition of betulin ethanol solvate at room temperature a new crystalline form of the biologically active compound betulin, namely hemihydrate of betulin, is obtained. By single crystal X-ray diffraction data the crystal structure of hemihydrate of betulin is determined. By powder X-ray thermodiffraction and differential scanning calorimetry it is found that when hemihydrate of betulin is heated to melting, Н2О molecules are removed and solid-phase transformations occur, which are related to the formation of an intermediate crystalline form andan orthorhombic modification of betulin.",

keywords = "betulin, polymorphism, pseudopolymorphism, solid-phase transformations, SOLVATOMORPHS, ISOSTRUCTURALITY, X-RAY",

author = "Drebushchak, {T. N.} and Mikhailovskaya, {A. V.} and Drebushchak, {V. A.} and Mikhailenko, {M. A.} and Myz{\textquoteright}, {S. A.} and Shakhtshneider, {T. P.} and Kuznetsova, {S. A.}",

year = "2020",

month = aug,

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doi = "10.1134/S0022476620080119",

language = "English",

volume = "61",

pages = "1260--1266",

journal = "Journal of Structural Chemistry",

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TY - JOUR

T1 - Crystalline form of betulin

T2 - polymorphism or pseudopolymorphism?

AU - Drebushchak, T. N.

AU - Mikhailovskaya, A. V.

AU - Drebushchak, V. A.

AU - Mikhailenko, M. A.

AU - Myz’, S. A.

AU - Shakhtshneider, T. P.

AU - Kuznetsova, S. A.

PY - 2020/8/1

Y1 - 2020/8/1

N2 - By recrystallization with different solvents as well as decomposition of betulin ethanol solvate at room temperature a new crystalline form of the biologically active compound betulin, namely hemihydrate of betulin, is obtained. By single crystal X-ray diffraction data the crystal structure of hemihydrate of betulin is determined. By powder X-ray thermodiffraction and differential scanning calorimetry it is found that when hemihydrate of betulin is heated to melting, Н2О molecules are removed and solid-phase transformations occur, which are related to the formation of an intermediate crystalline form andan orthorhombic modification of betulin.

AB - By recrystallization with different solvents as well as decomposition of betulin ethanol solvate at room temperature a new crystalline form of the biologically active compound betulin, namely hemihydrate of betulin, is obtained. By single crystal X-ray diffraction data the crystal structure of hemihydrate of betulin is determined. By powder X-ray thermodiffraction and differential scanning calorimetry it is found that when hemihydrate of betulin is heated to melting, Н2О molecules are removed and solid-phase transformations occur, which are related to the formation of an intermediate crystalline form andan orthorhombic modification of betulin.

KW - betulin

KW - polymorphism

KW - pseudopolymorphism

KW - solid-phase transformations

KW - SOLVATOMORPHS

KW - ISOSTRUCTURALITY

KW - X-RAY

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JO - Journal of Structural Chemistry

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