Crystalline form of betulin: polymorphism or pseudopolymorphism?

T. N. Drebushchak, A. V. Mikhailovskaya, V. A. Drebushchak, M. A. Mikhailenko, S. A. Myz’, T. P. Shakhtshneider, S. A. Kuznetsova

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


By recrystallization with different solvents as well as decomposition of betulin ethanol solvate at room temperature a new crystalline form of the biologically active compound betulin, namely hemihydrate of betulin, is obtained. By single crystal X-ray diffraction data the crystal structure of hemihydrate of betulin is determined. By powder X-ray thermodiffraction and differential scanning calorimetry it is found that when hemihydrate of betulin is heated to melting, Н2О molecules are removed and solid-phase transformations occur, which are related to the formation of an intermediate crystalline form andan orthorhombic modification of betulin.

Original languageEnglish
Pages (from-to)1260-1266
Number of pages7
JournalJournal of Structural Chemistry
Issue number8
Publication statusPublished - 1 Aug 2020


  • betulin
  • polymorphism
  • pseudopolymorphism
  • solid-phase transformations
  • X-RAY

Fingerprint Dive into the research topics of 'Crystalline form of betulin: polymorphism or pseudopolymorphism?'. Together they form a unique fingerprint.

Cite this