TY - JOUR
T1 - Crystal structure of 4-benzylcarbamoyl-1-methylpyridin-1-ium iodide
T2 - an efficient multimodal anti-viral drug
AU - Drebushchak, T. N.
AU - Kryukov, Yu A.
AU - Rogova, A. I.
AU - Boldyreva, E. V.
PY - 2017/7
Y1 - 2017/7
N2 - In the title compound, [MeC5H4NCONHCH2C6H5]I or C14H15N2O+·I-, a cation and an anion form an ionic pair linked by a strong N-H·I hydrogen bond. In the crystal, ionic pairs linked by weak C-H·I hydrogen bonds form infinite ribbons along the crystallographic a axis. Polymorphism screening varying crystallization solvents (water, acetone 90%-water, ethanol 90%-water, 2-propanol 90%-water, DMF, DMSO, methanol, acetonitrile) and conditions (solution temperature, heating and cooling protocols) did not reveal any other polymorphs than the one reported in this work.
AB - In the title compound, [MeC5H4NCONHCH2C6H5]I or C14H15N2O+·I-, a cation and an anion form an ionic pair linked by a strong N-H·I hydrogen bond. In the crystal, ionic pairs linked by weak C-H·I hydrogen bonds form infinite ribbons along the crystallographic a axis. Polymorphism screening varying crystallization solvents (water, acetone 90%-water, ethanol 90%-water, 2-propanol 90%-water, DMF, DMSO, methanol, acetonitrile) and conditions (solution temperature, heating and cooling protocols) did not reveal any other polymorphs than the one reported in this work.
KW - crystal structure
KW - drug
KW - polymorphism
UR - http://www.scopus.com/inward/record.url?scp=85023197405&partnerID=8YFLogxK
UR - https://www.elibrary.ru/item.asp?id=31055329
U2 - 10.1107/S2056989017008155
DO - 10.1107/S2056989017008155
M3 - Article
C2 - 28775862
AN - SCOPUS:85023197405
VL - 73
SP - 967
EP - 970
JO - Acta Crystallographica Section E: Crystallographic Communications
JF - Acta Crystallographica Section E: Crystallographic Communications
SN - 2056-9890
IS - Pt 7
ER -