Coronary artery calcification parameters in patients with coronary artery disease, depending on age, sex, and sex hormone levels

Oksana V. Tsygankova, Natalia E. Evdokimova, Yuliya I. Ragino, Konstantin Yu Nikolaev, Ludmila D. Latyntseva, Varvara V. Veretyuk

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The objective of this study was to compare the parameters of coronary calcification in men and women with coronary artery disease (CAD) depending on sex hormone levels and age. Subjects and Methods: We examined 281 patients: 147 women and 134 men aged between 35 years and 65 years who had a myocardial infarction ≥30 days before the examination. Levels of sex hormones (women-folliclestimulating hormone (FSH), testosterone; men testosterone, estradiol) were obtained by standard methods. Coronary artery calcification was assessed using multispiral computed tomography (MSCT). Results: In comparative analysis, in women, all multispiral computed tomography indicators of coronary artery calcification were significantly lower compared to men (p < 0.01). A multivariate analysis showed that coronary artery calcium score (CAC score) in women with CAD was directly dependent on testosterone levels, and in men with CAD – positively, on estradiol concentration ≥0.194 nmol/L, along with the direct effect of testosterone <12 nmol/L in men older than 55 years. Among men, age was significantly associated with an increase in coronary calcification. Conclusions: This study demonstrates the independent effect of sex steroids on coronary calcification and, above all, on the CAC score for women and men aged 35-65 years.

Original languageEnglish
Pages (from-to)287-298
Number of pages12
JournalWorld Heart Journal
Volume12
Issue number4
Publication statusPublished - 2020

Keywords

  • Coronary artery calcium score
  • Coronary artery disease
  • Coronary calcification
  • Estradiol
  • Follicle-stimulating hormone
  • Men
  • Testosterone
  • Women

OECD FOS+WOS

  • 3.02.DQ CARDIAC & CARDIOVASCULAR SYSTEMS

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