Copy number variants in genomes of local sheep breeds from Russia

A. V. Igoshin, T. E. Deniskova, A. A. Yurchenko, N. S. Yudin, A. V. Dotsev, M. I. Selionova, N. A. Zinovieva, D. M. Larkin

Research output: Contribution to journalArticlepeer-review

Abstract

Copy number variants (CNVs) are genomic structural variations that contribute to many adaptive and economically important traits in livestock. In this study, we detected CNVs in 354 animals from 16 Russian indigenous sheep breeds and analysed their possible functional roles. Our analysis of the entire sample set resulted in 4527 CNVs forming 1450 CNV regions (CNVRs). When constructing CNVRs for individual breeds, a total of 2715 regions ranging from 88 in Groznensk to 337 in Osetin breeds were identified. To make interbreed CNVR frequency comparison possible, we also identified core CNVRs using CNVs with overlapping chromosomal locations found in different breeds. This resulted in 137 interbreed CNVRs with frequency >15% in at least one breed. Functional enrichment analysis of genes affected by CNVRs in individual breeds revealed 12 breeds with significant enrichments in olfactory perception, PRAME family proteins, and immune response. Function of genes affected by interbreed and breed-specific CNVRs revealed candidates related to domestication, adaptation to high altitudes and cold climates, reproduction, parasite resistance, milk and meat qualities, wool traits, fat storage, and fat metabolism. Our work is the first attempt to uncover and characterise the CNV makeup of Russian indigenous sheep breeds. Further experimental and functional validation of CNVRs would help in developing new and improving existing sheep breeds.

Original languageEnglish
Pages (from-to)119-132
Number of pages14
JournalAnimal Genetics
Volume53
Issue number1
DOIs
Publication statusPublished - Feb 2022

Keywords

  • adaptation
  • copy number variant regions
  • copy number variants
  • economically important trait
  • local sheep breeds
  • PennCNV
  • Russian Federation
  • DNA Copy Number Variations
  • Russia
  • Animals
  • Sheep, Domestic/genetics
  • Genome
  • Wool

OECD FOS+WOS

  • 4.02 ANIMAL AND DAIRY SCIENCE
  • 1.06.KM GENETICS & HEREDITY
  • 1.06 BIOLOGICAL SCIENCES

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