Coordination Compounds of Cobalt(II), Nickel(II), and Copper(II) Halides with 2-Methyl-1,2,4-Triazolo[1,5-a]benzimidazole

I. I. Dyukova, T. A. Kuz’menko, V. Yu Komarov, T. S. Sukhikh, E. V. Vorontsova, L. G. Lavrenova

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1 Citation (Scopus)

Abstract

New coordination compounds of Co(II), Ni(II), and Cu(II) halides with 2-methyl-1,2,4-triazolo[1,5-a]benzimidazole (L), [Co(L)2Cl2] (Ia), [Ni(L)2(H2O)4]Cl2 · 4H2O (II), and [Сu2(L)4(µ-Br)2Br2] (IIIa), are synthesized. The complexes are studied by X-ray structure analysis (СIF files CCDC nos. 1825006–1825008), electronic (diffuse reflectance) spectroscopy, and IR spectroscopy. In compounds Ia, II, and IIIa, ligand L is coordinated to the metal by the N4 atom of the triazole fragment. The study of the cytotoxic effect of the ligand and synthesized complexes on the Hep-2 line (laryngeal cancer cells) shows a considerably higher activity of the copper(II) complex than that of the ligand.

Original languageEnglish
Pages (from-to)755-764
Number of pages10
JournalRussian Journal of Coordination Chemistry/Koordinatsionnaya Khimiya
Volume44
Issue number12
DOIs
Publication statusPublished - 1 Dec 2018

Keywords

  • 2-methyl-1,2,4-triazolo[1,5-a]benzimidazole
  • 3d metals
  • complexes
  • cytotoxic activity
  • electronic spectroscopy
  • IR spectroscopy
  • synthesis
  • X-ray structure analysis
  • 4-triazolo[1
  • CU(II)
  • 2-methyl-1
  • COMPLEXES
  • ANTIBACTERIAL
  • CO(II)
  • 1,2,4-TRIAZOLE
  • 5-a]benzimidazole
  • 2
  • PLATINUM(II)
  • BENZIMIDAZOLE
  • IMIDAZOLE
  • ANTIMICROBIAL ACTIVITY
  • THIABENDAZOLE

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