Cooling rate “window” in the crystallization of metacetamol form II

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Melting and crystallization of metacetamol (C8H9NO2, N-(3-hydroxyphenyl)acetamide, structural isomer of paracetamol) were measured using DSC cycling heating–cooling between room temperature and 165 °C with constant heating rate of 6 °C min−1 and variable cooling rate ranging from 3 to 24 °C min−1. The selection of the cooling rate allows us to control the crystallization of metacetamol into one of its two polymorphs, I or II. Pure form II of metacetamol (recently discovered) is crystallized after the cooling rate of 6 °C min−1. Increase or decrease in the cooling rate suppresses the crystallization of the form II and produces the form I with remnant amorphous phase and a small impurity of the form II. The melting points and enthalpies of fusion are 420 K and 26.0 ± 1.3 kJ mol−1 for the form I and 399 K and 21.3 ± 1.1 kJ mol−1 for the form II, respectively.

Original languageEnglish
Pages (from-to)1807-1814
Number of pages8
JournalJournal of Thermal Analysis and Calorimetry
Issue number2
Publication statusPublished - 1 Feb 2017


  • Cooling rate
  • DSC
  • Metacetamol
  • Polymorphism

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