Concomitant cocrystal and salt: no interconversion in the solid state

Evgeniy A. Losev; Elena Boldyreva

doi:10.1107/S2053229619001372

Concomitant cocrystal and salt: no interconversion in the solid state

Evgeniy A. Losev, Elena Boldyreva

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A cocrystal and a molecular salt of β-alanine and dl-tartaric acid, C ₃ H ₈ NO ₂ ⁺ ·C ₄ H ₄ O ₆ ⁻ , of the same chemical composition, were studied over a wide temperature range by single-crystal and powder X-ray diffraction. Neither the interconversion between the two phases nor any polymorphic transitions were observed in the temperature range from 100 K to the melting points. This contrasts with the solvent-mediated phase transition from the salt to the cocrystal in a slurry that has been documented earlier.

Original language	English
Pages (from-to)	313-319
Number of pages	7
Journal	Acta Crystallographica Section C: Structural Chemistry
Volume	75
DOIs	https://doi.org/10.1107/S2053229619001372
Publication status	Published - Mar 2019

Keywords

cocrystal
crystal structure
dl-tartaric acid
molecular salt
solvent-mediated phase transformation
X-ray diffraction
β-alanine
β-Alanine
DL-tartaric acid
Cocrystal
Molecular salt
Crystal structure
Solvent-mediated phase transformation
CRYSTALLIZATION
GLYCINE
RAMAN-SPECTROSCOPY
X-RAY-DIFFRACTION
POLYMORPHISM
LOW-TEMPERATURES
ACID CO-CRYSTALS
PHASE
beta-alanine
KINETICS

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10.1107/S2053229619001372

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title = "Concomitant cocrystal and salt: no interconversion in the solid state",

abstract = " A cocrystal and a molecular salt of β-alanine and dl-tartaric acid, C 3 H 8 NO 2 + ·C 4 H 4 O 6 − , of the same chemical composition, were studied over a wide temperature range by single-crystal and powder X-ray diffraction. Neither the interconversion between the two phases nor any polymorphic transitions were observed in the temperature range from 100 K to the melting points. This contrasts with the solvent-mediated phase transition from the salt to the cocrystal in a slurry that has been documented earlier. ",

keywords = "cocrystal, crystal structure, dl-tartaric acid, molecular salt, solvent-mediated phase transformation, X-ray diffraction, β-alanine, β-Alanine, DL-tartaric acid, Cocrystal, Molecular salt, Crystal structure, Solvent-mediated phase transformation, CRYSTALLIZATION, GLYCINE, RAMAN-SPECTROSCOPY, X-RAY-DIFFRACTION, POLYMORPHISM, LOW-TEMPERATURES, ACID CO-CRYSTALS, PHASE, beta-alanine, KINETICS",

author = "Losev, {Evgeniy A.} and Elena Boldyreva",

year = "2019",

month = mar,

doi = "10.1107/S2053229619001372",

language = "English",

volume = "75",

pages = "313--319",

journal = "Acta Crystallographica Section C: Structural Chemistry",

issn = "2053-2296",

publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - Concomitant cocrystal and salt

T2 - no interconversion in the solid state

AU - Losev, Evgeniy A.

AU - Boldyreva, Elena

PY - 2019/3

Y1 - 2019/3

N2 - A cocrystal and a molecular salt of β-alanine and dl-tartaric acid, C 3 H 8 NO 2 + ·C 4 H 4 O 6 − , of the same chemical composition, were studied over a wide temperature range by single-crystal and powder X-ray diffraction. Neither the interconversion between the two phases nor any polymorphic transitions were observed in the temperature range from 100 K to the melting points. This contrasts with the solvent-mediated phase transition from the salt to the cocrystal in a slurry that has been documented earlier.

AB - A cocrystal and a molecular salt of β-alanine and dl-tartaric acid, C 3 H 8 NO 2 + ·C 4 H 4 O 6 − , of the same chemical composition, were studied over a wide temperature range by single-crystal and powder X-ray diffraction. Neither the interconversion between the two phases nor any polymorphic transitions were observed in the temperature range from 100 K to the melting points. This contrasts with the solvent-mediated phase transition from the salt to the cocrystal in a slurry that has been documented earlier.

KW - cocrystal

KW - crystal structure

KW - dl-tartaric acid

KW - molecular salt

KW - solvent-mediated phase transformation

KW - X-ray diffraction

KW - β-alanine

KW - β-Alanine

KW - DL-tartaric acid

KW - Cocrystal

KW - Molecular salt

KW - Crystal structure

KW - Solvent-mediated phase transformation

KW - CRYSTALLIZATION

KW - GLYCINE

KW - RAMAN-SPECTROSCOPY

KW - X-RAY-DIFFRACTION

KW - POLYMORPHISM

KW - LOW-TEMPERATURES

KW - ACID CO-CRYSTALS

KW - PHASE

KW - beta-alanine

KW - KINETICS

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U2 - 10.1107/S2053229619001372

DO - 10.1107/S2053229619001372

M3 - Article

C2 - 30833526

AN - SCOPUS:85061487052

VL - 75

SP - 313

EP - 319

JO - Acta Crystallographica Section C: Structural Chemistry

JF - Acta Crystallographica Section C: Structural Chemistry

SN - 2053-2296

ER -

Concomitant cocrystal and salt: no interconversion in the solid state

Abstract

Keywords

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