Computational modeling of the cell-autonomous mammalian circadian oscillator

Olga A. Podkolodnaya; Natalya N. Tverdokhleb; Nikolay L. Podkolodnyy

doi:10.1186/s12918-016-0379-8

Computational modeling of the cell-autonomous mammalian circadian oscillator

Olga A. Podkolodnaya, Natalya N. Tverdokhleb, Nikolay L. Podkolodnyy

Computational Genomics Laboratory

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

This review summarizes various mathematical models of cell-autonomous mammalian circadian clock. We present the basics necessary for understanding of the cell-autonomous mammalian circadian oscillator, modern experimental data essential for its reconstruction and some special problems related to the validation of mathematical circadian oscillator models. This work compares existing mathematical models of circadian oscillator and the results of the computational studies of the oscillating systems. Finally, we discuss applications of the mathematical models of mammalian circadian oscillator for solving specific problems in circadian rhythm biology.

Original language	English
Article number	18
Pages (from-to)	379
Number of pages	16
Journal	BMC Systems Biology
Volume	11
Issue number	Suppl 1
DOIs	https://doi.org/10.1186/s12918-016-0379-8
Publication status	Published - 24 Feb 2017

Keywords

Mammalian circadian oscillator
Mathematical modeling
Circadian Clocks/genetics
Animals
Models, Biological
Gene Expression Regulation
Mammals/genetics
Mutation
PARAMETER-ESTIMATION
CYCLE OSCILLATORS
TRANSCRIPTION
ROBUST
RIBOSOME PROFILING REVEALS
PERIOD
SENSITIVITY-ANALYSIS
GENE-EXPRESSION
CLOCK
SYSTEMS BIOLOGY

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10.1186/s12918-016-0379-8

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abstract = "This review summarizes various mathematical models of cell-autonomous mammalian circadian clock. We present the basics necessary for understanding of the cell-autonomous mammalian circadian oscillator, modern experimental data essential for its reconstruction and some special problems related to the validation of mathematical circadian oscillator models. This work compares existing mathematical models of circadian oscillator and the results of the computational studies of the oscillating systems. Finally, we discuss applications of the mathematical models of mammalian circadian oscillator for solving specific problems in circadian rhythm biology.",

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