Computational modeling of the cell-autonomous mammalian circadian oscillator

Olga A. Podkolodnaya; Natalya N. Tverdokhleb; Nikolay L. Podkolodnyy

doi:10.1186/s12918-016-0379-8

Computational modeling of the cell-autonomous mammalian circadian oscillator

Olga A. Podkolodnaya, Natalya N. Tverdokhleb, Nikolay L. Podkolodnyy

Computational Genomics Laboratory

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

This review summarizes various mathematical models of cell-autonomous mammalian circadian clock. We present the basics necessary for understanding of the cell-autonomous mammalian circadian oscillator, modern experimental data essential for its reconstruction and some special problems related to the validation of mathematical circadian oscillator models. This work compares existing mathematical models of circadian oscillator and the results of the computational studies of the oscillating systems. Finally, we discuss applications of the mathematical models of mammalian circadian oscillator for solving specific problems in circadian rhythm biology.

Original language	English
Article number	18
Pages (from-to)	379
Number of pages	16
Journal	BMC Systems Biology
Volume	11
Issue number	Suppl 1
DOIs	https://doi.org/10.1186/s12918-016-0379-8
Publication status	Published - 24 Feb 2017

Keywords

Mammalian circadian oscillator
Mathematical modeling
Circadian Clocks/genetics
Animals
Models, Biological
Gene Expression Regulation
Mammals/genetics
Mutation
PARAMETER-ESTIMATION
CYCLE OSCILLATORS
TRANSCRIPTION
ROBUST
RIBOSOME PROFILING REVEALS
PERIOD
SENSITIVITY-ANALYSIS
GENE-EXPRESSION
CLOCK
SYSTEMS BIOLOGY

Access to Document

10.1186/s12918-016-0379-8

Link to publication in Scopus

Fingerprint Dive into the research topics of 'Computational modeling of the cell-autonomous mammalian circadian oscillator'. Together they form a unique fingerprint.

Cite this

@article{e424c54b4a0d4791810640760b890140,

title = "Computational modeling of the cell-autonomous mammalian circadian oscillator",

abstract = "This review summarizes various mathematical models of cell-autonomous mammalian circadian clock. We present the basics necessary for understanding of the cell-autonomous mammalian circadian oscillator, modern experimental data essential for its reconstruction and some special problems related to the validation of mathematical circadian oscillator models. This work compares existing mathematical models of circadian oscillator and the results of the computational studies of the oscillating systems. Finally, we discuss applications of the mathematical models of mammalian circadian oscillator for solving specific problems in circadian rhythm biology.",

keywords = "Mammalian circadian oscillator, Mathematical modeling, Circadian Clocks/genetics, Animals, Models, Biological, Gene Expression Regulation, Mammals/genetics, Mutation, PARAMETER-ESTIMATION, CYCLE OSCILLATORS, TRANSCRIPTION, ROBUST, RIBOSOME PROFILING REVEALS, PERIOD, SENSITIVITY-ANALYSIS, GENE-EXPRESSION, CLOCK, SYSTEMS BIOLOGY",

author = "Podkolodnaya, {Olga A.} and Tverdokhleb, {Natalya N.} and Podkolodnyy, {Nikolay L.}",

year = "2017",

month = feb,

day = "24",

doi = "10.1186/s12918-016-0379-8",

language = "English",

volume = "11",

pages = "379",

journal = "BMC Systems Biology",

issn = "1752-0509",

publisher = "BioMed Central Ltd.",

number = "Suppl 1",

}

TY - JOUR

T1 - Computational modeling of the cell-autonomous mammalian circadian oscillator

AU - Podkolodnaya, Olga A.

AU - Tverdokhleb, Natalya N.

AU - Podkolodnyy, Nikolay L.

PY - 2017/2/24

Y1 - 2017/2/24

N2 - This review summarizes various mathematical models of cell-autonomous mammalian circadian clock. We present the basics necessary for understanding of the cell-autonomous mammalian circadian oscillator, modern experimental data essential for its reconstruction and some special problems related to the validation of mathematical circadian oscillator models. This work compares existing mathematical models of circadian oscillator and the results of the computational studies of the oscillating systems. Finally, we discuss applications of the mathematical models of mammalian circadian oscillator for solving specific problems in circadian rhythm biology.

AB - This review summarizes various mathematical models of cell-autonomous mammalian circadian clock. We present the basics necessary for understanding of the cell-autonomous mammalian circadian oscillator, modern experimental data essential for its reconstruction and some special problems related to the validation of mathematical circadian oscillator models. This work compares existing mathematical models of circadian oscillator and the results of the computational studies of the oscillating systems. Finally, we discuss applications of the mathematical models of mammalian circadian oscillator for solving specific problems in circadian rhythm biology.

KW - Mammalian circadian oscillator

KW - Mathematical modeling

KW - Circadian Clocks/genetics

KW - Animals

KW - Models, Biological

KW - Gene Expression Regulation

KW - Mammals/genetics

KW - Mutation

KW - PARAMETER-ESTIMATION

KW - CYCLE OSCILLATORS

KW - TRANSCRIPTION

KW - ROBUST

KW - RIBOSOME PROFILING REVEALS

KW - PERIOD

KW - SENSITIVITY-ANALYSIS

KW - GENE-EXPRESSION

KW - CLOCK

KW - SYSTEMS BIOLOGY

UR - http://www.scopus.com/inward/record.url?scp=85013831092&partnerID=8YFLogxK

U2 - 10.1186/s12918-016-0379-8

DO - 10.1186/s12918-016-0379-8

M3 - Article

C2 - 28466791

AN - SCOPUS:85013831092

VL - 11

SP - 379

JO - BMC Systems Biology

JF - BMC Systems Biology

SN - 1752-0509

IS - Suppl 1

M1 - 18

ER -