Abstract
This review summarizes various mathematical models of cell-autonomous mammalian circadian clock. We present the basics necessary for understanding of the cell-autonomous mammalian circadian oscillator, modern experimental data essential for its reconstruction and some special problems related to the validation of mathematical circadian oscillator models. This work compares existing mathematical models of circadian oscillator and the results of the computational studies of the oscillating systems. Finally, we discuss applications of the mathematical models of mammalian circadian oscillator for solving specific problems in circadian rhythm biology.
Original language | English |
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Article number | 18 |
Pages (from-to) | 379 |
Number of pages | 16 |
Journal | BMC Systems Biology |
Volume | 11 |
Issue number | Suppl 1 |
DOIs | |
Publication status | Published - 24 Feb 2017 |
Keywords
- Mammalian circadian oscillator
- Mathematical modeling
- Circadian Clocks/genetics
- Animals
- Models, Biological
- Gene Expression Regulation
- Mammals/genetics
- Mutation
- PARAMETER-ESTIMATION
- CYCLE OSCILLATORS
- TRANSCRIPTION
- ROBUST
- RIBOSOME PROFILING REVEALS
- PERIOD
- SENSITIVITY-ANALYSIS
- GENE-EXPRESSION
- CLOCK
- SYSTEMS BIOLOGY