Computational modeling of the cell-autonomous mammalian circadian oscillator

Olga A. Podkolodnaya, Natalya N. Tverdokhleb, Nikolay L. Podkolodnyy

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

This review summarizes various mathematical models of cell-autonomous mammalian circadian clock. We present the basics necessary for understanding of the cell-autonomous mammalian circadian oscillator, modern experimental data essential for its reconstruction and some special problems related to the validation of mathematical circadian oscillator models. This work compares existing mathematical models of circadian oscillator and the results of the computational studies of the oscillating systems. Finally, we discuss applications of the mathematical models of mammalian circadian oscillator for solving specific problems in circadian rhythm biology.

Original languageEnglish
Article number18
Pages (from-to)379
Number of pages16
JournalBMC Systems Biology
Volume11
Issue numberSuppl 1
DOIs
Publication statusPublished - 24 Feb 2017

Keywords

  • Mammalian circadian oscillator
  • Mathematical modeling
  • Circadian Clocks/genetics
  • Animals
  • Models, Biological
  • Gene Expression Regulation
  • Mammals/genetics
  • Mutation
  • PARAMETER-ESTIMATION
  • CYCLE OSCILLATORS
  • TRANSCRIPTION
  • ROBUST
  • RIBOSOME PROFILING REVEALS
  • PERIOD
  • SENSITIVITY-ANALYSIS
  • GENE-EXPRESSION
  • CLOCK
  • SYSTEMS BIOLOGY

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