Comprehensive study of hexarhenium cluster complex Na4[{Re6Te8}(CN)6] – In terms of a new promising luminescent and X-ray contrast agent

Anna A. Krasilnikova, Anastasiya O. Solovieva, Anton A. Ivanov, Kristina E. Trifonova, Tatiana N. Pozmogova, Alphiya R. Tsygankova, Anton I. Smolentsev, Evgeniy I. Kretov, David S. Sergeevichev, Michael A. Shestopalov, Yuri V. Mironov, Alexander M. Shestopalov, Alexander F. Poveshchenko, Lidiya V. Shestopalova

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Octahedral rhenium cluster complexes may have considerable potential as therapeutic and diagnostic drugs due to their luminescent and X-ray contrast properties, as well as their ability to generate singlet oxygen upon photoirradiation. However, their potential biological effects and toxicity in vitro and in vivo are rather far from being understood. Thus, the aim of our research was to study cytotoxicity, intracellular localization and cellular uptake/elimination kinetics in vitro, biodistribution and acute intravenous toxicity in vivo of a complex Na4[{Re6Te8}(CN)6] as the promising compound for biomedical application. The results have demonstrated that the complex penetrates through cell membranes with the maximum accumulation in cells in 24 h of incubation and have low toxic effects in vitro and in vivo. The median lethal dose (LD50) of intravenously administrated Na4[{Re6Te8}(CN)6] is equal to 1082 ± 83 mg/kg. These findings will be useful for future development of cluster-based agents for different biomedical applications.

Original languageEnglish
Pages (from-to)755-763
Number of pages9
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume13
Issue number2
DOIs
Publication statusPublished - 1 Feb 2017

Keywords

  • Acute intravenous toxicity
  • Angiography
  • Intracellular localization
  • Tellurocyanide octahedral rhenium cluster complex
  • X-ray contrast agent
  • Tissue Distribution
  • Contrast Media
  • X-Rays
  • Humans
  • Luminescence
  • Rhenium
  • Tumor Cells, Cultured
  • PHOTODYNAMIC THERAPY
  • PHOTOSENSITIZERS
  • CANCER

Fingerprint Dive into the research topics of 'Comprehensive study of hexarhenium cluster complex Na<sub>4</sub>[{Re<sub>6</sub>Te<sub>8</sub>}(CN)<sub>6</sub>] – In terms of a new promising luminescent and X-ray contrast agent'. Together they form a unique fingerprint.

  • Cite this