Comparison of intravenous toxicity of hexaniobium cluster complex and its conjugate with gamma-cyclodextrin

Tatiana Pozmogova, Valentina Evsiukova, Anton Ivanov, Pavel Abramov, Yuri Vorotnikov, Anastsia Solovieva, Andrey Kushnarenko, Michael Shestopalov

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

Abstract

Cyclodextrins and their derivatives are widely used as drug delivery agents due to their ability to hold small molecules in their internal cavity. Reduction of toxicity by cyclodextrins is proven in the case of non-invasive or oral delivery of drugs, but the authors disagree on the intravenous use of these substances. In this paper, we compare two substances-the cluster complex of niobium [Nb6Cl12(H2O)6]2+ for which we previously showed anticancer activity, and its conjugate with cyclodextrin [Nb6Cl12(H2O)6]2+@\gamma-CD. To assess the effect of cyclodextrin on the toxicity of the solution, we intravenously administered a wide range of doses of two substances to BALB/C mice. After assessment of acute toxicity, the study of organ morphology was carried out. The results showed that conjugation with cyclodextrin not only did not reduce the toxicity of the cluster complex, but also increased it, causing vascular disorders in several organs.

Original languageEnglish
Title of host publicationSIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages326-329
Number of pages4
ISBN (Electronic)9781728144016
DOIs
Publication statusPublished - Oct 2019
Event2019 International Multi-Conference on Engineering, Computer and Information Sciences, SIBIRCON 2019 - Novosibirsk, Russian Federation
Duration: 21 Oct 201927 Oct 2019

Publication series

NameSIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings

Conference

Conference2019 International Multi-Conference on Engineering, Computer and Information Sciences, SIBIRCON 2019
CountryRussian Federation
CityNovosibirsk
Period21.10.201927.10.2019

Keywords

  • cyclodextrin
  • intravenous acute toxicity
  • morphology
  • niobium cluster complex

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