Comparative Subpopulation Analysis of Plasma Exosomes from Cancer Patients

S. N. Tamkovich, N. V. Yunusova, A. K. Somov, S. G. Afanas’ev, G. V. Kakurina, E. S. Kolegova, E. A. Tugutova, P. P. Laktionov, I. V. Kondakova

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Pre-selection of tumor exosomes from a total pool of circulating microvesicles is an important stage required to increase sensitivity and specificity of the developing methods for diagnostics of oncological diseases. In this study, universal proteins characterized by increased expression in plasma exosomes have been identified in patients with colorectal cancer, head and neck squamous cell carcinomas, and lung cancer. The use of antibodies against major exosomal proteins will help to develop a simple and high-performance method of affinity isolation of tumor exosomes.

Original languageEnglish
Pages (from-to)151-155
Number of pages5
JournalBiochemistry (Moscow) Supplement Series B: Biomedical Chemistry
Volume12
Issue number2
DOIs
Publication statusPublished - 1 Apr 2018

Keywords

  • colorectal cancer
  • exosomes
  • flow cytometry
  • head and neck squamous cell carcinoma
  • lung cancer
  • protein spectrum
  • transmission electron microscopy

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