Chemogenetic Activation of Glutamatergic Neurons in the Juvenile Rat Cortex Reduces Anxiety

N. N. Dygalo, D. A. Lanshakov, N. P. Komysheva, U. S. Drozd, E. V. Shaburova, E. V. Sukhareva, G. T. Shishkina

Research output: Contribution to journalArticlepeer-review

Abstract

Chemogenetic activation of glutamatergic neurons of the prefrontal cortex reduces the manifestations of psychoemotional anxiety during the juvenile period of ontogenesis. This result is the first evidence of feasibility of targeted chemogenetic control of neuronal activity during the early stages of brain development.

Original languageEnglish
Pages (from-to)16-18
Number of pages3
JournalDoklady Biochemistry and Biophysics
Volume490
Issue number1
DOIs
Publication statusPublished - 1 Jan 2020

Keywords

  • anxiety
  • chemogenetics
  • glutamatergic neurons
  • juvenile period of ontogenesis
  • prefrontal cortex

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