Chemical Reaction Monitoring using Zero-Field Nuclear Magnetic Resonance Enables Study of Heterogeneous Samples in Metal Containers

Dudari B. Burueva, James Eills, John W. Blanchard, Antoine Garcon, Román Picazo-Frutos, Kirill V. Kovtunov, Igor V. Koptyug, Dmitry Budker

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

We demonstrate that heterogeneous/biphasic chemical reactions can be monitored with high spectroscopic resolution using zero-field nuclear magnetic resonance spectroscopy. This is possible because magnetic susceptibility broadening is negligible at ultralow magnetic fields. We show the two-step hydrogenation of dimethyl acetylenedicarboxylate with para-enriched hydrogen gas in conventional glass NMR tubes, as well as in a titanium tube. The low frequency zero-field NMR signals ensure that there is no significant signal attenuation arising from shielding by the electrically conductive sample container. This method paves the way for in situ monitoring of reactions in complex heterogeneous multiphase systems and in reactors made of conductive materials while maintaining resolution and chemical specificity.

Original languageEnglish
Pages (from-to)17026-17032
Number of pages7
JournalAngewandte Chemie - International Edition
Volume59
Issue number39
Early online date8 Jun 2020
DOIs
Publication statusPublished - 21 Sep 2020

Keywords

  • catalysis
  • hyperpolarization
  • NMR spectroscopy
  • reaction monitoring
  • zero-field
  • PARA-HYDROGEN
  • SPIN DYNAMICS
  • NMR-SPECTROSCOPY
  • PARAHYDROGEN
  • FLOW
  • KINETICS
  • CHEMISTRY
  • COUPLINGS
  • CATIONIC RHODIUM COMPLEXES
  • POLARIZATION TRANSFER

OECD FOS+WOS

  • 1.04 CHEMICAL SCIENCES

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