Characteristics of p-type and n-type photoelectrochemical biosensors: A case study for esophageal cancer detection

Joseph Hang Leung, Hong Thai Nguyen, Shih Wei Feng, Sofya B. Artemkina, Vladimir E. Fedorov, Shang Chin Hsieh, Hsiang Chen Wang

Research output: Contribution to journalArticlepeer-review

Abstract

P-type and N-type photoelectrochemical (PEC) biosensors were established in the laboratory to discuss the correlation between characteristic substances and photoactive material properties through the photogenerated charge carrier transport mechanism. Four types of human esophageal cancer cells (ECCs) were analyzed without requiring additional bias voltage. Photoelectrical characteristics were examined by scanning electron microscopy (SEM), X-ray diffraction (XRD), UV–vis reflectance spectroscopy, and photocurrent response analyses. Results showed that smaller pho-tocurrent was measured in cases with advanced cancer stages. Glutathione (L-glutathione reduced, GSH) and Glutathione disulfide (GSSG) in cancer cells carry out redox reactions during carrier separation, which changes the photocurrent. The sensor can identify ECC stages with a certain level of photoelectrochemical response. The detection error can be optimized by adjusting the number of cells, and the detection time of about 5 min allowed repeated measurement.

Original languageEnglish
Article number1065
JournalNanomaterials
Volume11
Issue number5
DOIs
Publication statusPublished - May 2021

Keywords

  • Esophageal squamous cell carcinoma
  • Glutathione
  • Photoelectrochemical biosensor
  • Transient photocurrent

OECD FOS+WOS

  • 2.05 MATERIALS ENGINEERING
  • 2.04 CHEMICAL ENGINEERING

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