Chapter 21: Fast Field-cycling NMR Experiments with Hyperpolarized Spins

Alexey S. Kiryutin, Konstantin L. Ivanov, Alexandra V. Yurkovskaya, Hans Martin Vieth

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Abstract

This chapter gives an overview of field-cycling applications for the control of nuclear spin order in hyperpolarized spin ensembles. Such methods are used for strong signal enhancement in NMR spectroscopy, for the preservation of non-thermal order and for the analysis of the polarization process. We focus on techniques that are operative in the condensed phase and exploit processes based on light irradiation. Such techniques include optical nuclear polarization (ONP), chemically induced dynamic nuclear polarization (CIDNP) and optical pumping (OP). Alternatively, we start from the singlet spin order of para-hydrogen, the singlet spin isomer of the H2 molecule. This approach is known as para-hydrogen-induced polarization (PHIP) and in a slightly different version as signal amplification by reversible exchange (SABRE). Since in all methods polarization is transferred from primarily polarized spins to target spins, we also review existing methods for polarization transfer. After describing the theoretical framework, we present examples of instrumentation for field cycling in the range between 5 nT and 9.4 T, and subsequently discuss characteristic applications. Advantages and challenges of field cycling in spin hyperpolarization are discussed and perspectives in this field are addressed.

Original languageEnglish
Title of host publicationOptimizing NMR Methods for Structure Elucidation
Subtitle of host publicationCharacterizing Natural Products and Other Organic Compounds
EditorsR Kimmich
PublisherRoyal Society of Chemistry
Chapter21
Pages512-562
Number of pages51
Edition18
ISBN (Electronic)9781782625391, 9781788010740, 9781788011549
ISBN (Print)978-1-78801-154-9
DOIs
Publication statusPublished - 2018

Publication series

NameNew Developments in NMR
Number18
Volume2019-January
ISSN (Print)2044-253X
ISSN (Electronic)2044-2548

Keywords

  • OPTICAL NUCLEAR-POLARIZATION
  • LEVEL ANTI-CROSSINGS
  • PARAHYDROGEN INDUCED POLARIZATION
  • CHEMICAL HYDROGEN ABSTRACTION
  • MULTINUCLEAR RADICAL PAIRS
  • SHUTTLE DNP SPECTROMETER
  • DOPED FLUORENE CRYSTALS
  • EXCITED TRIPLET-STATES
  • TIME-RESOLVED CIDNP
  • N-ACETYL HISTIDINE

OECD FOS+WOS

  • 1.04.EA CHEMISTRY, ANALYTICAL

State classification of scientific and technological information

  • 31.19 Analytical chemistry

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