Changes in Activity of Cysteine Cathepsins B and L in Brain Structures of Mice with Aggressive and Depressive-Like Behavior Formed under Conditions of Social Stress

S. Ya Zhanaeva, A. A. Rogozhnikova, E. L. Alperina, M. M. Gevorgyan, G. V. Idov

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We studied activity of lysosomal cysteine proteases, cathepsins B and L, in brain structures (frontal cortex, caudate nucleus, hippocampus, and hypothalamus) of C57Bl/6J mice with aggressive and depressive-like behavior formed under conditions of chronic social stress (repeated experience of victories and defeats within 20 days). Mice with depressive-like behavior showed increased activity of cathepsin В in the hypothalamus and nucleus caudatus and increased activity of cathepsin L in the hippocampus compared to control animals not subjected to agonistic confrontations. In mice with aggressive behavior, protease activity in the studied brain structures was not changed. In 4 h after immune system activation with LPS (250 μg/kg), cathepsin L activity in the hippocampus of control mice increased in comparison with mice receiving saline. In contrast to control animals, LPS caused a decrease in activity of the enzyme in the caudate nucleus and frontal cortex of aggressive mice and in the hippocampus of mice with depressive-like behavior.

Original languageEnglish
Pages (from-to)425-429
Number of pages5
JournalBulletin of Experimental Biology and Medicine
Volume164
Issue number4
DOIs
Publication statusPublished - 1 Mar 2018

Keywords

  • aggressive and depressive-like behavior
  • brain structures
  • cathepsins B and L
  • chronic social stress
  • INHIBITION
  • ALZHEIMERS-DISEASE
  • MODEL
  • ASSOCIATION
  • DEFICIENCY

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