Abstract

Despite the significant progress in cancer cure, the development of new approaches to cancer therapy is still of great importance since many deadly tumors remain untreatable. Boron neutron capture therapy (BNCT), proposed more than eighty years ago, is still considered a potentially advantageous approach. Irradiation of cells containing B-10 isotopes with epithermal neutrons and the consequent decay of boron nuclei releases particles that deposit high energy along a very short path, inflicting heavy damage on the target cells but sparing the neighbouring tissue. Delivery and preferential accumulation of boron in cancer cells are the major obstacles that slow down the clinical use of BNCT. Since DNA damage caused by irradiation is the major reason for cell death, the incorporation of boron-containing nucleotides into the DNA of cancer cells may significantly increase the efficacy of BNCT. In this review, we discuss the current state of knowledge in the synthesis of boron-containing nucleosides and their application for BNCT with a special focus on their possible incorporation into genomic DNA.

Original languageEnglish
Pages (from-to)4668-4682
Number of pages15
JournalAmerican journal of cancer research
Volume11
Issue number10
Publication statusPublished - 2021

Keywords

  • Boron neutron capture therapy
  • therapeutic nucleosides
  • carboranes
  • DNA damage
  • DNA repair
  • drug metabolism
  • HUMAN APURINIC/APYRIMIDINIC ENDONUCLEASE
  • 3-CARBORANYL THYMIDINE ANALOGS
  • NUCLEOTIDE EXCISION-REPAIR
  • THYMINE DNA-GLYCOSYLASE
  • BIOLOGICAL EVALUATION
  • DELIVERY AGENTS
  • EXONUCLEASE ACTIVITY
  • POLYMERASE-EPSILON
  • DRUG-RESISTANCE
  • CANCER

OECD FOS+WOS

  • 3.02.DM ONCOLOGY

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