Biosensors Based on SOI Nanowire Transistors for Biomedicine and Virusology

O. V. Naumova, V. M. Generalov, E. G. Zaitseva, A. V. Latyshev, A. L. Aseev, S. A. Pyankov, I. V. Kolosova, G. G. Ananko, A. P. Agafonov, E. V. Gavrilova, R. A. Maksyutov, A. S. Safatov

Research output: Contribution to journalArticlepeer-review

Abstract

This article contains the results of research on the topical problem of highly sensitive express registration of biological objects using field-effect transistors with the surface open for analyte access, which are made based on silicon-on-insulator (SOI) films. The possibilities of dielectrophoretic effects for controlling the concentration of the analyte in the area of sensory elements are considered on the example of the indication of viruses of nuclear polyhedrosis and vaccinia. It is shown that the use of the dielectrophoresis (DEPh) effect makes it possible to solve (1) the key tasks for creating sensor systems: increasing the detecting ability, as well as exrtacting and verifying the signal from the target particles; and (2) the fundamental task: determining the charge state of the analyte in solutions without modifying the sensors’ surface. The problems and prospects of the mass application of nanowire (NW) biosensors, including those with the dielectrophoretic effect, in biotechnology, virology, etc., are discussed.

Original languageEnglish
Pages (from-to)137-145
Number of pages9
JournalRussian Microelectronics
Volume50
Issue number3
DOIs
Publication statusPublished - May 2021

OECD FOS+WOS

  • 2.02 ELECTRICAL ENG, ELECTRONIC ENG
  • 2.05 MATERIALS ENGINEERING
  • 1.03 PHYSICAL SCIENCES AND ASTRONOMY

State classification of scientific and technological information

  • 34.25 Virology

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