Biodegradable poly(L-lactide)/calcium phosphate composites with improved properties for orthopedics: Effect of filler and polymer crystallinity

Varvara A. Demina, Sergei V. Krasheninnikov, Alexander I. Buzin, Roman A. Kamyshinsky, Natalya V. Sadovskaya, Evgeny N. Goncharov, Natalya A. Zhukova, Mikhail V. Khvostov, Alla V. Pavlova, Tatjana G. Tolstikova, Nikita G. Sedush, Sergei N. Chvalun

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Biodegradable poly(L-lactide)/calcium phosphate composites are promising materials for fabrication of bone fixation implants with improved properties. Multistage compounding was proposed as an efficient method for the preparation of biodegradable poly(L-lactide)/calcium phosphate composites with submicron filler dispersion and mechanical characteristics similar to native bone. The improvement of the characteristics is caused both by the filler itself and by the increase of polymer crystallinity due to the nucleation effect. The technique allows to fabricate biodegradable composites with controlled properties by varying concentration and type of the filler as well as degree of PLLA matrix crystallinity. Animal studies revealed that all the composites were biocompatible and non-toxic.

Original languageEnglish
Article number110813
Number of pages8
JournalMaterials Science and Engineering C
Volume112
DOIs
Publication statusPublished - Jul 2020

Keywords

  • Biodegradable polymers
  • Bone tissue engineering
  • Hydroxyapatite
  • Polylactide
  • Polymer composites
  • SURFACE-MODIFIED HYDROXYAPATITE
  • TRICALCIUM PHOSPHATE
  • IMPLANTS
  • MECHANICAL-PROPERTIES
  • PHASE
  • DEGRADATION
  • BONE
  • SCAFFOLDS
  • NANOTECHNOLOGY

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