Benzopentathiepine derivative, 8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153), as a promising antidepressant of new generation

Elizabeth A. Kulikova, Konstantin P. Volcho, Nariman F. Salakhutdinov, Alexander V. Kulikov

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

Background: Depressive disorders are among four leading causes of burden among the most disabling medical illnesses and antidepressant drugs (AD) occupying leading positions in the worldwide pharmaceutical market. However, typical AD show prolonged delay, refractory and adverse side effects. Methodology: The review analyzes experimental data and theoretical models of possible antidepressant effect of benzopentathiepine, 8-(trifluoromethyl)-1,2,3,4,5 - benzopentathiepin-6- amine hydrochloride (TC-2153). The antidepressant effect of TC-2153 is based on its ability to inhibit striatal enriched protein tyrosine phosphatase (STEP)- an enzyme that plays a key role in the intraneuronal transduction of signals from receptors of classic neurotransmitters and the brain derived neurotrophic factor (BDNF). The mechanism underlying antidepressant effect of TC-2153 includes increase in production as well as intracellular effect of BDNF on neuronal survival and neurogenesis. Results and Conclusion: There is no visible mechanisms of delay, refractory and adverse side effects of TC-2153. Thus, TC-2153 is a promising drug of new generation of atypical AD.

Original languageEnglish
Pages (from-to)974-984
Number of pages11
JournalLetters in Drug Design and Discovery
Volume14
Issue number8
DOIs
Publication statusPublished - 1 Aug 2017

Keywords

  • Antidepressant
  • BDNF
  • depression
  • serotonin
  • STEP
  • TC-2153

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