Beam shaping assembly design of 7Li(p,n)7Be neutron source for boron neutron capture therapy of deep-seated tumor

L. Zaidi, M. Belgaid, S. Taskaev, R. Khelifi

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

The development of a medical facility for boron neutron capture therapy at Budker Institute of Nuclear Physics is under way. The neutron source is based on a tandem accelerator with vacuum insulation and lithium target. The proposed accelerator is conceived to deliver a proton beam around 10 mA at 2.3 MeV proton beam. To deliver a therapeutic beam for treatment of deep-seated tumors a typical Beam Shaping Assembly (BSA) based on the source specifications has been explored. In this article, an optimized BSA based on the 7Li(p,n)7Be neutron production reaction is proposed. To evaluate the performance of the designed beam in a phantom, the parameters and the dose profiles in tissues due to the irradiation have been considered. In the simulations, we considered a proton energy of 2.3 MeV, a current of 10 mA, and boron concentrations in tumor, healthy tissues and skin of 52.5 ppm, 15 ppm and 22.5 ppm, respectively. It is found that, for a maximum punctual healthy tissue dose seated to 11 RBE-Gy, a mean dose of 56.5 RBE Gy with a minimum of 52.2 RBE Gy can be delivered to a tumor in 40 min, where the therapeutic ratio is estimated to 5.38. All of these calculations were carried out using the Monte Carlo MCNP code.

Original languageEnglish
Pages (from-to)316-324
Number of pages9
JournalApplied Radiation and Isotopes
Volume139
DOIs
Publication statusPublished - 1 Sep 2018

Keywords

  • Li(p,n)Be neutron generator reaction
  • Accelerator-based BNCT
  • Beam shaping assembly
  • In-phantom parameters
  • Li-7(p,n)Be-7 neutron generator reaction
  • TARGET
  • FACILITY
  • ACCELERATOR-BASED BNCT
  • I CLINICAL-TRIAL
  • BSA
  • REACTION NEAR-THRESHOLD
  • OPTIMIZATION
  • DOSIMETRY
  • Humans
  • Glioblastoma/radiotherapy
  • Radioisotopes
  • Lithium/radiation effects
  • Beryllium/radiation effects
  • Equipment Design
  • Computer Simulation
  • Radiotherapy Planning, Computer-Assisted
  • Boron Neutron Capture Therapy/instrumentation
  • Radiotherapy Dosage
  • Brain Neoplasms/radiotherapy
  • Phantoms, Imaging

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