Aqueous, Heterogeneous para-Hydrogen-Induced 15N Polarization

Liana B. Bales, Kirill V. Kovtunov, Danila A. Barskiy, Roman V. Shchepin, Aaron M. Coffey, Larisa M. Kovtunova, Andrey V. Bukhtiyarov, Matthew A. Feldman, Valerii I. Bukhtiyarov, Eduard Y. Chekmenev, Igor V. Koptyug, Boyd M. Goodson

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

The successful transfer of para-hydrogen-induced polarization to 15N spins using heterogeneous catalysts in aqueous solutions was demonstrated. Hydrogenation of a synthesized unsaturated 15N-labeled precursor (neurine) with parahydrogen (p-H2) over Rh/TiO2 heterogeneous catalysts yielded a hyperpolarized structural analogue of choline. As a result, 15N polarization enhancements of over 2 orders of magnitude were achieved for the 15N-labeled ethyltrimethylammonium ion product in deuterated water at elevated temperatures. Enhanced 15N NMR spectra were successfully acquired at 9.4 and 0.05 T. Importantly, long hyperpolarization lifetimes were observed at 9.4 T, with a 15N T1 of ∼6 min for the product molecules, and the T1 of the deuterated form exceeded 8 min. Taken together, these results show that this approach for generating hyperpolarized species with extended lifetimes in aqueous, biologically compatible solutions is promising for various biomedical applications.

Original languageEnglish
Pages (from-to)15304-15309
Number of pages6
JournalJournal of Physical Chemistry C
Volume121
Issue number28
DOIs
Publication statusPublished - 20 Jul 2017

Keywords

  • DYNAMIC NUCLEAR-POLARIZATION
  • FIELD
  • HYPERPOLARIZED MAGNETIC-RESONANCE
  • IN-VIVO
  • MRI
  • NMR
  • PARAHYDROGEN-INDUCED POLARIZATION
  • PASADENA HYPERPOLARIZATION
  • REVERSIBLE EXCHANGE
  • SPIN ORDER

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