Application of fMRI and Simultaneous fMRI-EEG Neurofeedback in Post-Stroke Motor Rehabilitation

D. D. Bezmaternykh, K. V. Kalgin, P. E. Maximova, M. Ye Mel’nikov, E. D. Petrovskii, E. V. Predtechenskaya, A. A. Savelov, A. A. Semenikhina, T. N. Tsaplina, M. B. Shtark, A. V. Shurunova

Research output: Contribution to journalArticlepeer-review

Abstract

This article discusses the contribution of fMRI- and fMRI-EEG-neurofeedback into recovery of motor function in two subacute stroke patients during the early post-stroke period. Premotor and supplementary motor zones of the cortex were chosen as the targets of voluntary control. Patient 1 received 6 sessions of motor imagery-based fMRI neurofeedback of secondary motor areas activity and Patient 2 received a similar course with the addition of μ- and β-EEG activity suppression. Both reduced the motor deficit severity, improved on the quality of life, and increased the C3/C4 coherence to other central leads within EEG μ-band. Patient 1 reliably increased the fMRI signal in target areas and improved on the strength and speed of hand movements. Patient 2 (fMRI-EEG) mastered the EEG activity regulation to a greater degree. The authors conclude that pure fMRI neurofeedback and bi-modal fMRI-EEG neurofeedback produce different clinical effects in motor rehabilitation, which confirms the prospect of the closed-loop stroke treatment.

Original languageEnglish
Pages (from-to)379-383
Number of pages5
JournalBulletin of Experimental Biology and Medicine
Volume171
Issue number3
DOIs
Publication statusPublished - Jul 2021

Keywords

  • EEG μ band
  • fMRI neurofeedback
  • ischemic stroke
  • motor imagery
  • supplementary motor area

OECD FOS+WOS

  • 1.06 BIOLOGICAL SCIENCES
  • 3.01.QA MEDICINE, RESEARCH & EXPERIMENTAL

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