Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells

T. S. Frolova, A. V. Lipeeva, D. S. Baev, Y. A. Tsepilov, O. I. Sinitsyna

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Pentacyclic triterpene acids are of great interest as compounds that exhibit selective cytotoxicity against malignant tumor cells. If earlier studies were carried out mainly in cancer cells of epithelial origin, in the present work the cytotoxic effect of ursolic and pomolic acids on the primary and permanent glioma cell lines was analyzed. Both compounds are toxic to oncotransformed cells and induce apoptosis in U-87 MG line. Using molecular docking, it has been shown that Akt1 and MDM2 may be potential targets of the studied triterpene acids. It has been suggested that ursolic and pomolic acids induce apoptosis in glioma cells through inhibition of the PI3K/Akt signaling pathway, and they can be considered as potentially promising agents for the treatment of glioblastoma.

Original languageEnglish
Pages (from-to)809-816
Number of pages8
JournalMolekuliarnaia biologiia
Volume51
Issue number5
DOIs
Publication statusPublished - 1 Sep 2017

Keywords

  • apoptosis
  • glioma
  • pomolic acid
  • selective cytotoxicity
  • ursolic acid

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