Antiulcerogenic activity of borneol derivatives

M. S. Borisova, O. I. Yarovaya, M. D. Semenova, T. G. Tolstikova, N. F. Salakhutdinov

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Antiulcerogenic activity of borneol and its N-heterocyclic esters was investigated using indomethacin-induced gastric ulcer model. A considerable antiulcerogenic effect comparable to that shown by Omeprazole and Famotidine was found for two investigated compounds in the indomethacin-induced gastric ulcer model. Bornyl 2-piperazinoacetate, with a non-substituted piperazine moiety, showed maximum antiulcerogenic activity in the indomethacininduced gastric ulcer model and demonstrated a significant gastroprotective effect in the ethanol-induced gastric ulcer model comparable to the effect of Omeprazole.

Original languageEnglish
Pages (from-to)558-561
Number of pages4
JournalRussian Chemical Bulletin
Volume67
Issue number3
DOIs
Publication statusPublished - 1 Mar 2018

Keywords

  • antiulcerogenic activity
  • borneol derivatives

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