Antiulcerogenic activity of borneol derivatives

M. S. Borisova, O. I. Yarovaya, M. D. Semenova, T. G. Tolstikova, N. F. Salakhutdinov

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    Antiulcerogenic activity of borneol and its N-heterocyclic esters was investigated using indomethacin-induced gastric ulcer model. A considerable antiulcerogenic effect comparable to that shown by Omeprazole and Famotidine was found for two investigated compounds in the indomethacin-induced gastric ulcer model. Bornyl 2-piperazinoacetate, with a non-substituted piperazine moiety, showed maximum antiulcerogenic activity in the indomethacininduced gastric ulcer model and demonstrated a significant gastroprotective effect in the ethanol-induced gastric ulcer model comparable to the effect of Omeprazole.

    Original languageEnglish
    Pages (from-to)558-561
    Number of pages4
    JournalRussian Chemical Bulletin
    Volume67
    Issue number3
    DOIs
    Publication statusPublished - 1 Mar 2018

    Keywords

    • antiulcerogenic activity
    • borneol derivatives

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