Angiopoietin-Like Proteins 4 (ANGPTL4) Gene Polymorphisms and Risk of Brain Arteriovenous Malformation

Sarafroz A. Erkinova, Ekaterina A. Sokolova, Kirill Y. Orlov, Vitaly S. Kiselev, Nikolay V. Strelnikov, Andrey V. Dubovoy, Elena N. Voronina, Maxim L. Filipenko

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    3 Citations (Scopus)

    Abstract

    Background: Brain arteriovenous malformations (BAVMs) are formed by hypertrophied arterial vessels (afferents, feeders), a large number of arteriovenous shunts which become tangled to form a body (nidus) of malformation, which then expands draining proximal veins. The aim of this study was a replication of single nucleotide polymorphism (SNP) rs11672433 association with BAVM development with the subsequent meta-analysis of published data. Methods: A total of 252 Russian patients with brain BAVMs and 480 control subjects were included in the present study. Genotyping was performed using real-time polymerase chain reaction with competitive hydrolysis probes. Results: In our case-control study, we found no significant association with brain arteriovenous malformation for the SNP rs11672433 of ANGPTL4 gene (odds ratio .82, 95% confidence interval = .57-1.17 P value = .27) as well as in meta-analysis (odds ratio 1.18, 95% confidence interval = .81-1.73, P value = .39). Conclusions: Our data showed that SNP rs11672433 was not associated with the BAVM Russian population and the following meta-analysis did not detect an association in total. Thus, in spite of the fact that ANGPTL4 (protein) participates in the angiogenesis regulation processes, we consider that SNP rs11672433, a high-frequency locus in the ANGPTL4 gene, does not influence the predisposition to BAVM or its effect is too small to be detected in the present size sample set.

    Original languageEnglish
    Pages (from-to)908-913
    Number of pages6
    JournalJournal of Stroke and Cerebrovascular Diseases
    Volume27
    Issue number4
    DOIs
    Publication statusPublished - 1 Apr 2018

    Keywords

    • Angiopoietin-like proteins 4 (ANGPTL4)
    • Arteriovenous malformations
    • Association
    • Gene
    • Single nucleotide polymorphisms
    • gene
    • association
    • angiopoietin-like proteins 4 (ANGPTL4)
    • single nucleotide polymorphisms
    • ASSOCIATION
    • Angiopoietin-like 4 Protein/genetics
    • Humans
    • Middle Aged
    • Male
    • Case-Control Studies
    • Russia
    • Young Adult
    • Adult
    • Female
    • Odds Ratio
    • Genetic Predisposition to Disease
    • Genetic Association Studies
    • Intracranial Arteriovenous Malformations/diagnosis
    • Gene Frequency
    • Risk Factors
    • Chi-Square Distribution
    • Phenotype
    • Polymorphism, Single Nucleotide

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