Representation analysis of miRNA from clarified urine and urine microvesicles in prostate malignancies and non-malignant neoplasms

I. A. Zaporozhchenko, O. E. Bryzgunova, E. A. Lekchnov, I. D. Osipov, M. M. Zaripov, Yu B. Yurchenko, S. V. Yarmoschuk, O. A. Pashkovskaya, E. Yu Rykova, A. A. Zheravin, P. P. Laktionov

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Urine of prostate cancer patients contains tumor-specific biopolymers, including protein- and microvesicles associated miRNAs that can potentially be used as oncomarkers. Previously we have characterized urine extracellular vesicles and demonstrated diagnostic potential of their miRNA cargo. In this study, we have performed a comparative analysis of the expression of 84 miRNA in paired samples of urine microvesicles and clarified urine from healthy men, patients with benign hyperplasia and cancer of the prostate using miRCURY LNA miRNA qPCR Panels. Subsets of miRNAs with differences in expression between the fractions of the urine were found in all three groups. Two groups of miRNA were identified based on the patterns of their differential expression. They regulate several key signaling pathways associated with prostate cancer development.

Translated title of the contributionAnaliz predstavlennosti mikroRNK v mikrovezikulakh mochi i beskletochnoĭ moche pri zabolevaniiakh predstatel'noĭ zhelezy
Original languageEnglish
Pages (from-to)38-45
Number of pages8
JournalBiomeditsinskaya Khimiya
Volume64
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Exosomes
  • Microvesicles
  • MiRNA
  • Prostate cancer
  • Urine

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