Abstract

The report is about an assessment of a beam at an accelerator neutron source at Budker Institute of Nuclear Physics and its possible application on glioblastoma tumor. An evaluation of the efficacy of boron neutron capture therapy on heterotopic glioblastoma U87 MG in SCID mice using different boron containing drugs was carried out. Accumulation of 10B in tumor and normal tissues was detected using atomic emission spectrometer ICPE-9820 (Shimadzu, Japan). Tumor growth was significantly slower in all irradiated groups from the 7th day after BNCT compared to untreated control group. The differences between experimental groups became significant from the 50th day after BNCT. Liposomal BSH showed better long-term results compared to BPA and non-liposomal BSH.
Original languageEnglish
Title of host publication19th International Congress on Neutron Capture Therapy Granada, Spain, September 27th - October 1st, 2021. Book of Abstacts
Place of PublicationВена
PublisherInternational Atomic Energy Agency
Pages152
Number of pages1
Publication statusPublished - 2021
Event19th International Congress on Neutron Capture Therapy - Вена, Austria
Duration: 27 Sep 20211 Oct 2021
Conference number: 19
http://www.icnct19.org/

Conference

Conference19th International Congress on Neutron Capture Therapy
Abbreviated titleICNCT
CountryAustria
CityВена
Period27.09.202101.10.2021
Internet address

OECD FOS+WOS

  • 2.02.IQ ENGINEERING, ELECTRICAL & ELECTRONIC

State classification of scientific and technological information

  • 47.31 Accelerators of charged particles and plasma

Fingerprint

Dive into the research topics of 'Accelerator-based boron neutron capture therapy: in vivo experiments'. Together they form a unique fingerprint.

Cite this