A study of plant coumarins 16*. Synthesis and transformations of 7-alkynylcoumarins

Alla V. Lipeeva, Elvira E. Shults

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6 Citations (Scopus)

Abstract

[Figure not available: see fulltext.] 7-Alkynyl-substituted coumarins were synthesized by a Sonogashira reaction of 6-substituted 7-(trifluoromethylsulfonyloxy)coumarins with terminal acetylenes. The reaction of 7-ethynyl-substituted coumarins with azidobenzoic acids in the presence of copper(II) sulfate and sodium ascorbate was used to synthesize the respective 7-[(1-carboxyphenyl)-1H-1,2,3-triazol-4-yl]coumarins.

Original languageEnglish
Pages (from-to)1302-1309
Number of pages8
JournalChemistry of Heterocyclic Compounds
Volume53
Issue number12
DOIs
Publication statusPublished - 1 Dec 2017
Externally publishedYes

Keywords

  • 1,2,3-triazoles
  • arylalkynes
  • coumarins
  • CuААС reaction
  • Sonogashira reaction
  • Cu reaction
  • METABOLITES
  • HECK
  • MEDICINAL CHEMISTRY
  • CROSS-COUPLING REACTIONS
  • CuAAC reaction
  • ANTICANCER
  • AGENTS
  • HYBRIDS

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