N-glycosylation of IgG affects ligand binding, antigen recognition and modulates immune response. IgG N- glycome is altered in many pathological states, including cancers, autoimmune and inflammatory diseases. However, the causal relationships between diseases and IgG N-glycosylation traits remain enigmatic. In the current study we implement a Mendelian Randomization approach to study causal effect of IgG N-glycan traits on 12 diseases and vice versa. We have found limited genetic evidence that increased risk of systemic lupus erythematosus might lead to increased bisection of IgG N- glycans.
|Number of pages||2|
|Publication status||Published - 2020|
|Event||Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia) - ICG SB RAS, Новосибирск, Russian Federation|
Duration: 6 Jul 2020 → 10 Jul 2020
Conference number: 12
|Conference||Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia)|
|Period||06.07.2020 → 10.07.2020|