A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases

Research output: Contribution to conferenceAbstractpeer-review

Abstract

N-glycosylation of IgG affects ligand binding, antigen recognition and modulates immune response. IgG N- glycome is altered in many pathological states, including cancers, autoimmune and inflammatory diseases. However, the causal relationships between diseases and IgG N-glycosylation traits remain enigmatic. In the current study we implement a Mendelian Randomization approach to study causal effect of IgG N-glycan traits on 12 diseases and vice versa. We have found limited genetic evidence that increased risk of systemic lupus erythematosus might lead to increased bisection of IgG N- glycans.
Original languageEnglish
Pages134-135
Number of pages2
DOIs
Publication statusPublished - 2020
EventBioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia) - ICG SB RAS, Новосибирск, Russian Federation
Duration: 6 Jul 202010 Jul 2020
Conference number: 12
https://bgrssb.icgbio.ru/2020/

Conference

ConferenceBioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia)
Abbreviated titleBGRS/SB-2020
CountryRussian Federation
CityНовосибирск
Period06.07.202010.07.2020
Internet address

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