A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases

Olga O. Zaitseva, Sodbo Z. Sharapov, Lucija Klaric, Gordan Lauc, Yakov A. Tsepilov

Research output: Contribution to journalMeeting Abstractpeer-review

Abstract

N-glycosylation of IgG affects ligand binding, antigen recognition and modulates immune response. IgG N- glycome is altered in many pathological states, including cancers, autoimmune and inflammatory diseases. However, the causal relationships between diseases and IgG N-glycosylation traits remain enigmatic. In the current study we implement a Mendelian Randomization approach to study causal effect of IgG N-glycan traits on 12 diseases and vice versa. We have found limited genetic evidence that increased risk of systemic lupus erythematosus might lead to increased bisection of IgG N- glycans.
Original languageEnglish
Pages (from-to)1132-1132
Number of pages1
JournalGlycobiology
Volume30
Issue number12
Publication statusPublished - Dec 2020

OECD FOS+WOS

  • 1.06 BIOLOGICAL SCIENCES

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