A search for synthetic routes to tetrabenzylglycoluril

Anastasia A. Sinitsyna, Sergey G. Il’yasov, Maya V. Chikina, Ilia V. Eltsov, Andrey A. Nefedov

Research output: Contribution to journalArticle

Abstract

In this study, a search for synthetic routes to never-before-seen tetrabenzylglycoluril was made and two synthetic strategies were examined: condensation of 1,3-dibenzylurea with glyoxal, and N-alkylation of glycoluril and its disubstituted derivative. The first synthetic approach furnished only a condensation product, 3,3′-bi(6,8-dibenzyl-2,4-dioxa-9,8-diazabicyclo[3.3.0]octan-7-one, bearing the dioxolane moiety, in 24% yield. The second method in which 2,6-dibenzylglycoluril was reacted with BnCl in acetonitrile in the presence of KOH for 3 h afforded the target product tetrabenzylglycoluril in over 60% yield.

Original languageEnglish
Pages (from-to)1019-1025
Number of pages7
JournalChemical Papers
Volume74
Issue number3
DOIs
Publication statusPublished - 1 Mar 2020

Keywords

  • Benzylation
  • Condensation
  • Glycoluril
  • Glyoxal
  • Tetrabenzylglycoluril

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