A New DNA Break Repair Pathway Involving PARP3 and Base Excision Repair Proteins

E. A. Belousova, M. M. Kutuzov, P. A. Ivankina, A. A. Ishchenko, O. I. Lavrik

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    Poly(ADP-ribosyl)ation, which is catalyzed by PARP family proteins, is one of the main reactions in the cell response to genomic DNA damage. Massive impact of DNA-damaging agents (such as oxidative stress and ionizing radiation) causes numerous breaks in DNA. In this case, the development of a fast cell response, which allows the genomic DNA integrity to be retained, may be more important than the repair by more accurate but long-term restoration of the DNA structure. This is the first study to show the possibility of eliminating DNA breaks through their PARP3-dependent mono(ADP-ribosyl)ation followed by ligation and repair of the formed ribo-AP sites by the base excision repair (BER) enzyme complex. Taken together, the results of the studies on ADP-ribosylation of DNA and the data obtained in this study suggest that PARP3 may be a component of the DNA break repair system involving the BER enzyme complex.

    Original languageEnglish
    Pages (from-to)233-237
    Number of pages5
    JournalDoklady Biochemistry and Biophysics
    Volume482
    Issue number1
    DOIs
    Publication statusPublished - 1 Sep 2018

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