A New Bias Site for Epigenetic Modifications: How Non-Canonical GC Base Pairs Favor Mechanochemical Cleavage of DNA

Denis A. Semyonov, Ilia V. Eltsov, Yury D. Nechipurenko

Research output: Contribution to journalArticlepeer-review

Abstract

Properties of non-canonical GC base pairs and their relations with mechanochemical cleavage of DNA are analyzed. A hypothesis of the involvement of the transient GC wobble base pairs both in the mechanisms of the mechanochemical cleavage of DNA and epigenetic mechanisms involving of 5-methylcytosine, is proposed. The hypothesis explains the increase in the frequency of the breaks of the sugar-phosphate backbone of DNA after cytosines, the asymmetric character of these breaks, and an increase in break frequency in CpG after cytosine methylation. As an alternative hypothesis, probable implication of GC+ Hoogsteen base pairs is considered, which now exemplify the best-studied non-canonical GC base pairs in the DNA double helix. Also see the video abstract here https://youtu.be/EUunVWL0ptw.

Original languageEnglish
Article number2000051
Number of pages8
JournalBioEssays
Volume42
Issue number11
DOIs
Publication statusPublished - 1 Nov 2020

Keywords

  • 5-methylcytosines
  • mechanochemical cleavage of DNAs
  • molecular basis of epigenetics
  • tautomers
  • transient base pairs in DNAs
  • wobble base pairs
  • MUTAGENESIS
  • DEAMINATION
  • 5-METHYLCYTOSINE
  • CYTOSINE
  • NUCLEIC-ACIDS
  • N-4-METHOXYCYTOSINE
  • EQUILIBRIUM
  • TAUTOMERS
  • 5-FORMYLCYTOSINE
  • INSIGHTS

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